Month: April 2022

Kostka, Miroslav; Zimcik, Petr; Miletin, Miroslav; Klemera, Petr; Kopecky, Kamil; Musil, Zbynek published the article 《Comparison of aggregation properties and photodynamic activity of phthalocyanines and azaphthalocyanines》. Keywords: phthalocyanine preparation aggregation photodynamic property; azaphthalocyanine preparation aggregation photodynamic property.They researched the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ).Synthetic Route of C6Cl2N4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56413-95-7) here.

Phthalocyanines (Pc) and their aza-analogs azaphthalocyanines (AzaPc) (tetrapyrazinoporphyrazines) with eight n-octylsulfanyl or tert-butylsulfanyl peripheral substituents and different central metals (Mg, Zn, metal-free) were synthesized. Dimerization constants Kd and absorption spectra of pure monomeric and dimeric magnesium complexes in toluene were calculated using series of absorbances at different concentrations The bulky tert-butylsulfanyl substituents were found to be much better inhibitors of aggregation than long alkyl chains. Also Pc are less aggregated in organic solvents then AzaPc, short explanation is given. Singlet oxygen production of Pc and AzaPc was compared using dye-sensitized photooxidation of 1,3-diphenylisobenzofuran in pyridine. Both Pc and AzaPc showed similar activity not dependent on type of peripheral substitution. Zinc complexes of both Pc and AzaPc exceeded the magnesium ones and metal-free dyes in singlet oxygen production approx. twice.

In addition to the literature in the link below, there is a lot of literature about this compound(5,6-Dichloropyrazine-2,3-dicarbonitrile)Synthetic Route of C6Cl2N4, illustrating the importance and wide applicability of this compound(56413-95-7).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Phenol-Substituted Tetrapyrazinoporphyrazines: pH-Dependent Fluorescence in Basic Media, published in 2015, which mentions a compound: 56413-95-7, mainly applied to zinc phenol substituted tetrapyrazinoporphyrazine preparation pH dependent fluorescence; phenol deprotonation switching off red fluorescence tetrapyrazinoporphyrazine solution microemulsion; azaphthalocyanines; fluorescence; intramolecular charge transfer; pH sensors; phthalocyanines, Related Products of 56413-95-7.

Tetrapyrazinoporphyrazines (TPyzPzs) bearing one, two, four or eight 3,5-di(tert-butyl)-4-hydroxyphenol moieties were synthesized as Zn(II) complexes and metal-free derivatives The deprotonation of the phenol using Bu4NOH induced the formation of a strong donor for intramol. charge transfer that switched OFF the red fluorescence (λF∼660 nm) of the parent Zn TPyzPzs. The changes were fully reversible for TPyzPzs with one to four phenolic moieties, and an irreversible modification was observed for TPyzPzs substituted with eight phenols. The sensors were anchored to lipophilic particles in H2O, and a pKa ∼12.5-12.7 was determined for the phenolic hydroxyl based on fluorescence changes in different buffers. A novel concept for fluorescence OFF-ON-OFF switching in metal-free TPyzPzs bearing phenolic moieties upon addition of specific amounts of base was demonstrated.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3685-23-2, is researched, SMILESS is N[C@H]1CC[C@H](CC1)C(O)=O, Molecular C7H13NO2Journal, Article, Xenobiotica called Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril, Author is Kaye, B.; Brearley, C. J.; Cussans, N. J.; Herron, M.; Humphrey, M. J.; Mollatt, A. R., the main research direction is candoxatril candoxatrilat pharmacokinetics species.Quality Control of cis-4-Aminocyclohexane carboxylic acid.

Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo in the mouse, rat, rabbit, dog and man. Oral doses of [14C]candoxatril were cleared rapidly, mostly by ester hydrolysis to candoxatrilat, in the mouse, dog and man. A complementary i.v. study in man with [14C]candoxatrilat showed that the active drug was virtually completely renally cleared. Neither candoxatril nor candoxatrilat underwent chiral inversion in man. The systemic availability of candoxatrilat from the oral prodrug was estimated to be 88, 53, 42, 17 and 32% in the mouse, rat, rabbit, dog and man resp. Plasma clearance of candoxatril was too rapid to enable pharmacokinetic parameter calculation in mice and rabbits; for man, the apparent oral clearance was 57.9 mL/min/kg and the elimination half-life was 0.46 h. For i.v. candoxatrilat, total plasma clearance values were 32, 15, 5.5, 5.8 and 1.9 mL/min/kg for the mouse, rat, rabbit, dog and man, resp. Renal clearance values were 8.7, 7.2, 2.9 and 1.7 mL/min/kg for the mouse, rat, dog and man, resp., and these approximated the resp. glomerular filtration rates. Allometric scaling with respect to body weight across the species allowed reasonable prediction of the above 2 clearance parameters in man.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Kopecky, Kamil; Zimcik, Petr; Novakova, Veronika; Miletin, Miroslav; Musil, Zbynek; Stribna, Jana published the article 《The synthesis and characterization of metal-free, unsymmetrical azaphthalocyanines with hydroxy groups and their complex formation with pyridine》. Keywords: azaphthalocyanine pyridine complex preparation dye.They researched the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ).Recommanded Product: 5,6-Dichloropyrazine-2,3-dicarbonitrile. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56413-95-7) here.

Three, unsym. metal-free azaphthalocyanines (AzaPc) were prepared using the statistical condensation of 5,6-bis(diethylamino)-pyrazine-2,3-dicarbonitrile (A) and the pyrazinedicarbonitrile (B) substituted with alkylamine chains bearing one or two hydroxy groups. The desired AAAB type, metal-free compounds were isolated, purified and characterized; the compounds contain one or two hydroxy groups that can be modified with suitable ligands. The mechanism leading to the unusual formation of a new morpholine ring during the preparation of some pyrazinedicarbonitriles is explained. Metal-free AzaPcs form a proton-transfer complex with two mols. of pyridine, this complex formation being accompanied by a change of solution color from purple to blue. The complex is formed directly with two mols. of pyridine, one on either side of the macrocycle. The rate constants of this process were found to be of the order ∼10-4 s-1; the rate of complex formation was not the same for all compounds and may depend on the AzaPc structure. The influence of hydroxy groups on the rate constant was not confirmed.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 616-43-3, is researched, SMILESS is CC1=CNC=C1, Molecular C5H7NReport, called Substances labeled in metabolically stable positions. 9. Synthesis of pyridine by thermal rearrangement of amines containing the C5N structure, Author is Chebani, K.; Zessin, J.; Steinbach, J., the main research direction is thermal rearrangement amine; pyrrole thermal rearrangement; pyridine thermal rearrangement amine.Related Products of 616-43-3.

Thermal rearrangement of N-methylbutylamine, N-methylpyrrole, 4-(N-methylamino)butanol and N-methyl-3-pyrrolidinol produces mixtures of various substances which contain pyridine as the basic structure. Only aromatic systems are stable under the reaction conditions.

In addition to the literature in the link below, there is a lot of literature about this compound(3-Methyl-1H-pyrrole)Related Products of 616-43-3, illustrating the importance and wide applicability of this compound(616-43-3).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Quality Control of 3-Methyl-1H-pyrrole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Steric and Electronic Effects in Methyl-Substituted 2,2′-Bipyrroles and Poly(2,2′-Bipyrrole)s: Part I. Synthesis and Characterization of Monomers and Polymers. Author is Benincori, Tiziana; Brenna, Elisabetta; Sannicolo, Franco; Zotti, Gianni; Zecchin, Sandro; Schiavon, Gilberto; Gatti, Carlo; Frigerio, Giovanni.

The effects of N- and C-Me substitution on the elec. and spectral properties of pyrrole, 2,2′-bipyrrole, and the corresponding polymers were investigated. A whole series of monomethyl and N- or Cβ-dimethyl-substituted 2,2′-bipyrroles was synthesized, and the electrochem. and spectral properties of all the compounds were investigated under identical testing conditions. The corresponding polymers were prepared by electrochem. anodic oxidation under comparable exptl. conditions and their spectroscopic and conductivity properties evaluated for comparison. The higher degree of efficiency in transmission of electronic effects associated with Me substitution at Cβ with respect to substitution at N was clearly demonstrated. The influence of the symmetry of the starting monomer (C2v or Cs) on the elec. properties of the resulting polymers is discussed.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Highly efficient synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles through a one-pot palladium-catalyzed coupling reaction/cyclization in water, published in 2012-06-20, which mentions a compound: 56413-95-7, Name is 5,6-Dichloropyrazine-2,3-dicarbonitrile, Molecular C6Cl2N4, Name: 5,6-Dichloropyrazine-2,3-dicarbonitrile.

A highly efficient one-pot synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles is presented. The reaction of 5-(alkyl/arylamino)-6-chloropyrazine-2,3-dicarbonitriles with phenylacetylene, catalyzed by Pd-Cu, in the presence of SDS as the surfactant in water, leads to the desired products in good-to-high yields.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stefan, Klaus Peter; Schuhmann, Wolfgang; Parlar, Harun; Korte, Friedhelm researched the compound: 3-Methyl-1H-pyrrole( cas:616-43-3 ).Recommanded Product: 616-43-3.They published the article 《The synthesis of new 3-substituted pyrroles》 about this compound( cas:616-43-3 ) in Chemische Berichte. Keywords: silylpyrrole; pyrrole silyl; desilylation silylpyrrole. We’ll tell you more about this compound (cas:616-43-3).

The synthesis of 3-alkyl-, 3-(ω-bromoalkyl)-, 3-iodo-, 3-formyl-, 3-acetyl-1-(triisopropylsilyl)pyrrole, 2-[1-(triisopropylsilyl)-3-pyrrolyl]-2-propanol, 1-(triisopropylsilyl)-3-pyrrolecarboxylic acid, and 7-[1-(triisopropylsilyl)-3-pyrrolyl]heptanoic acid as well as the desilylation of these products to the corresponding 3-substituted pyrroles is described. Intermediates in these syntheses are 1-(triisopropylsilyl)pyrrole, 3-bromo-, and 3-litho-1-(triisopropylsilyl)pyrrole.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Recommanded Product: 616-43-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Pyrolysis of fast-growing aquatic biomass -Lemna minor (duckweed): Characterization of pyrolysis products. Author is Muradov, Nazim; Fidalgo, Beatriz; Gujar, Amit C.; T-Raissi, Ali.

The aim of this work was to conduct the exptl. study of pyrolysis of fast-growing aquatic biomass -Lemna minor (commonly known as duckweed) with the emphasis on the characterization of main products of pyrolysis. The yields of pyrolysis gas, pyrolytic oil (bio-oil) and char were determined as a function of pyrolysis temperature and the sweep gas (Ar) flow rate. Thermogravimetric/differential thermogravimetric (TG/DTG) analyses of duckweed samples in inert (helium gas) and oxidative (air) atm. revealed differences in the TG/DTG patterns obtained for duckweed and typical plant biomass. The bio-oil samples produced by duckweed pyrolysis at different reaction conditions were analyzed using GC-MS technique. It was found that pyrolysis temperature had minor effect on the bio-oil product slate, but exerted major influence on the relative quantities of the individual pyrolysis products obtained. While, the residence time of the pyrolysis vapors had negligible effect on the yield and composition of the duckweed pyrolysis products.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile(SMILESS: N#CC1=NC(Cl)=C(Cl)N=C1C#N,cas:56413-95-7) is researched.Name: 3-Methyl-1H-pyrrole. The article 《2-Sulfanylidene-1,3-dithiolo[4,5-b]pyrazine-5,6-dicarbonitrile》 in relation to this compound, is published in IUCrData. Let’s take a look at the latest research on this compound (cas:56413-95-7).

In the title compound, C7N4S3, the mol. entity consisting of a 1,3-dithiole-2-thione with a fused pyrazine ring is planar, with an r.m.s. deviation of 0.042 (3) Å from the least-squares plane. In the crystal, mols. are linked via short intermol. S···N contacts [3.251 (4) and 3.308 (3) Å] between the S atom of the thiocarbonyl group and N atoms of the cyano groups.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate