Month: April 2022

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of an octadecapeptide and its 18-amide analog corresponding to the first eighteen amino acid residues of corticotropin (ACTH) and their biological activities》. Authors are Otsuka, Hideo; Inouye, Ken; Shinozaki, Fusako; Kanayama, Makoto.The article about the compound:cis-4-Aminocyclohexane carboxylic acidcas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O).Recommanded Product: 3685-23-2. Through the article, more information about this compound (cas:3685-23-2) is conveyed.

The title compound (I) and its 18-amide analog (II) were synthesized. The activities of I, II, H-Gly-Tyr-Ser-Met-Glu-His-Phe-Arg-Try-Gly-Lys-Pro-Val-Gly-Arg-Arg-OH (III) (CA 63, 670f), and H-Gly-Tyr-Ser-Met-Glu-His-Phe-Arg-Try-Gly-Lys-Pro-Val-Gly-Lys-Arg-Arg-NH2 (IV) (CA 63, 16462d) were compared (cf. the table). (BOC = tert-BuO2C and Cbz = PhCH2O2C). Steroidogenic U.S.P. units/mg., Lipolytic minimal effective dose (γ); In vivo, In vitro, Rabbit, Rat; I, 17.07, 9.35, 0.000075, 0.0045; II, 39.6;58.0, 4.7;11.5, 0.000004, 0.0027; III, 0.124, 0.134, 0.00093, 0.021; IV, 2.72; 1.26, 0.00042, 0.0037; Coupling of BOC-Ser-Tyr-Ser-Met-N3 with H-Glu(γ-tert-Bu)-His-Phe-Arg-Try-Gly-OH gave BOC-Ser-Tyr-Ser-Met-Glu(γ-tert-Bu)-His-Phe-Arg-Try-Gly-OH (V), m. 202° (decomposition), [α]24D -13.2° (c 1.0, HCONMe2). Reaction of Cbz-Lys(BOC)-Pro-Val-Gly-Lys(BOC)-N3 with either H-Lys(BOC)-Arg-Arg-OH or its amide gave Cbz-Lys(BOC)-Pro-Val-Gly-Lys(BOC)-Lys(BOC)-Arg-Arg-OH (VI), [α]25.5D -46.1° (c 1.0, 50% AcOH), or its amide (VII), [α]22.5D -43.7° (c 1.75, 50% AcOH). Coupling of N-hydroxysuccinimide ester of V with the hydrogenolyzed VI or VII gave BOC-Ser-Tyr-Ser-Met-Glu(γ-tert-Bu)-His-Phe-Arg-Try-Gly-Lys(BOC)-Pro-Val-Gly-Lys(BOC)-Lys(BOC)-Arg-Arg-OH (VIII) or its amide (IX), resp. VIII was purified on carboxymethyl cellulose columns and treated with 90% F3CCO2H to give I, λ (0.1N NaOH) 281.5 mμ (ε 7030), 288.5 mμ (ε 6820), [α]25D -54.6° (c 0.5, 0.1N AcOH). Similarly, IX gave II, λ (0.1N NaOH) 281.5 mμ (ε 7050), 288.5 mμ (ε 6740), [α]24D -55.8° (c 0.5, 0.1N AcOH). Amino acid analysis of I and II confirmed their structures.

The article 《Synthesis of an octadecapeptide and its 18-amide analog corresponding to the first eighteen amino acid residues of corticotropin (ACTH) and their biological activities》 also mentions many details about this compound(3685-23-2)Recommanded Product: 3685-23-2, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

SDS of cas: 56413-95-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Preparation of magnesium azaphthalocyanines by cyclotetramerization of S-substituted 4,5-disulfanylpyrazine-2,3-dicarbonitriles. Author is Mrkved, Eva H.; Holmaas, Lars T.; Kjsen, Helge; Hvistendahl, Georg.

Four novel S-substituted 4,5-disulfanylpyrazine-2,3-dicarbonitriles were obtained in a multistep synthesis from diaminomaleonitrile. Two of these dicarbonitriles, with Et or benzyl S-substituents, give pure Mg azaphthalocyanines in good yields when reacted with Mg propoxide in PrOH and dioxane. Aromatic S-substituents are less stable during the reaction conditions used for cyclizations, and product mixtures were obtained.

The article 《Preparation of magnesium azaphthalocyanines by cyclotetramerization of S-substituted 4,5-disulfanylpyrazine-2,3-dicarbonitriles》 also mentions many details about this compound(56413-95-7)SDS of cas: 56413-95-7, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) called Synthesis of peptides containing cis- or trans-3- or 4-aminocyclohexanecarboxylic acid residues, Author is Skaric, Vinko; Kovacevic, Mice; Skaric, Djurdja, which mentions a compound: 3685-23-2, SMILESS is N[C@H]1CC[C@H](CC1)C(O)=O, Molecular C7H13NO2, Application of 3685-23-2.

Et tert-butoxycarbonylphenylalanyl-trans- and -cis-4-aminocyclohexanecarboxylates were prepared by coupling the N-hydroxysuccinimido ester of tert-butoxycarbonylphenylalanine with a mixture of isomers of Et 4-aminocyclohexanecarboxylate. Treatment of the hydroxysuccinimido esters of tert-butoxycarbonylphenylalanyl-trans-4- and -cis-3-aminocyclohexanecarboxylic acids with S-benzylcysteine Me ester gave tert-butoxycarbonylphenylalanyl-trans-4- and -cis-3-aminocyclohexylcarbonyl-S-benzylcysteine Me ester.

The article 《Synthesis of peptides containing cis- or trans-3- or 4-aminocyclohexanecarboxylic acid residues》 also mentions many details about this compound(3685-23-2)Application of 3685-23-2, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Synthesis and characterization of N-Mannich bases with pyrimethamine for antimicrobial activities, the main research direction is bactericide fungicide Mannich isatin pyrimethamine Schiff base; antibacterial isatin pyrimethamine Mannich Schiff base.Application In Synthesis of 3-Methyl-1H-pyrrole.

Schiff bases of isatin with pyrimethamine and its N-Mannich bases were synthesized. Antimicrobial evaluation was done by agar dilution method against 10 pathogenic bacteria and 4 pathogenic fungi. The new derivatives exhibited higher potency compared to the standard drugs against all organisms (against all bacteria). All the compounds exhibited antifungal activity.

The article 《Synthesis and characterization of N-Mannich bases with pyrimethamine for antimicrobial activities》 also mentions many details about this compound(616-43-3)Application In Synthesis of 3-Methyl-1H-pyrrole, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Category: chiral-oxygen-ligands. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Management induced organic matter differentiation in grassland and arable soil: a study using pyrolysis techniques. Author is Nierop, Klaas G. J.; Pulleman, Mirjam M.; Marinissen, Joke C. Y..

Differences in agricultural management and land use lead to differences in soil structure, soil organic matter (SOM) dynamics and composition We investigated the SOM composition at 3 depth layers in a permanent pasture (PP), an organic arable (OA) and a conventional arable (CA) field within one soil series in marine loam deposits in The Netherlands. Both arable fields were in the grass phase of the rotation. The chem. composition of SOM was determined by a combination of conventional pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS) and of thermally-assisted hydrolysis and methylation (THM) with tetramethylammonium hydroxide (TMAH). In PP, SOM was composed of relatively little decomposed, mainly grass-derived material comprising polysaccharides, lignin, aliphatic compounds (extractable lipids, cutin, suberin) and proteins. With depth, plant-derived constituents decreased, whereas microbial and humified material predominated. Both arable soils contained mainly strongly humified plant material and microbially altered proteineous material that showed heterocyclic N-compounds together with alkylbenzenes and phenols upon pyrolysis. With THM, small traces of plant-derived alkanols and cutin/suberin were observed in the arable soils. The upper layers of OA contained little lignin, which can only be derived from the grass vegetation or manure inputs since last plowing (2 yr before), since it was not found in the whole plow layer. Overall SOM composition is therefore hardly affected by organic farming compared to conventional management. The differences in SOM content and composition between the pasture and arable fields can be ascribed to differences in input and depth distribution of fresh organic materials. A difference in phys. protection of easily mineralizable SOM between pasture and arable soils is also likely to contribute.

The article 《Management induced organic matter differentiation in grassland and arable soil: a study using pyrolysis techniques》 also mentions many details about this compound(616-43-3)Category: chiral-oxygen-ligands, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Gardini, Gian P. published the article 《Simple oxidation products from 2- and 3-methylpyrrole and hydrogen peroxide》. Keywords: pyrrole oxidation; oxidation pyrrole; peroxide pyrrolyl.They researched the compound: 3-Methyl-1H-pyrrole( cas:616-43-3 ).Name: 3-Methyl-1H-pyrrole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:616-43-3) here.

2-Methylpyrrole (I) and 3-methylpyrrole (II) were subjected to oxidation with 36% H2O2. Thus, a mixture of I + H2O2 (molar ratio 1:1.4) in EtOH-Et2O was lef t at room temperature 10 days to yield 42% III, m. 154° (decomposition). Similarly, II was oxidized (molar ratio II-H2O2 1:2.5) 24 hr at 10° to yield 53% IV, m. 95-6° (sublimed 85°/0.5 mm). Ir spectral data were given.

After consulting a lot of data, we found that this compound(616-43-3)Name: 3-Methyl-1H-pyrrole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Alen, Jo; De Borggraeve, Wim M.; Compernolle, Frans; Hoornaert, Georges J. published the article 《Evaluation of the β-turn-inducing properties of an analog of (amino)piperidinonecarboxylates》. Keywords: beta turn mimetic acetylamino cyclohexanecarboxamide preparation.They researched the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ).Recommanded Product: 3685-23-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3685-23-2) here.

Cis-4-(Acetylamino)-N-(methyl)cyclohexanecarboxamide has been selected as all carbon ring analog of previously described 5-(amino)piperidinone-2-carboxylate systems. The potential β-turn-inducing properties of this model compound are evaluated by means of NMR anal. and mol. modeling. It was found that suitable as β-turn-inducing scaffold. Apparently, the planar lactam function in the native (amino)(oxo)piperidinecarboxylate systems is important to impose a correct conformation for β-turn induction.

After consulting a lot of data, we found that this compound(3685-23-2)Recommanded Product: 3685-23-2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Mitsuhashi, Keiryo; Nagae, Yasushi; Suzuki, Toshinobu published the article 《Synthesis of pyrido[1′,2′:1,2]imidazo[4,5-b]pyrazines from 2-amino-3-chloro-5,6-dicyanopyrazine with substituted pyridines》. Keywords: pyridoimidazopyrazine; aminochlorodicyanopyrazine cyclocondensation pyridine.They researched the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ).Name: 5,6-Dichloropyrazine-2,3-dicarbonitrile. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56413-95-7) here.

Novel synthesis of the title compounds by the cyclization between 2-amino-3-chloro-5,6-dicyanopyrazine (I) and various substituted pyridines is described. E.g., heating I with pyridines II (R = Me, Pr, Me3C, PhCH2, CONH2, CO2Me, Ph, 2-pyridyl) in DMF at 90° for 48 h gave 14-72% pyridoimidazopyrazines III.

After consulting a lot of data, we found that this compound(56413-95-7)Name: 5,6-Dichloropyrazine-2,3-dicarbonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Quality Control of cis-4-Aminocyclohexane carboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis of peptidelike derivatives of cis- and trans-4-aminocyclohexanecarboxylic acids containing sarcolysin residues. Author is Karpavicius, K.; Patockiene, L.; Knunyants, I. L..

Mixed-anhydride and dicyclohexylcarbodiimide coupling reactions of N-formysarcolysin and N-(benzyloxycarbonyl)sarcolysin with cis- and trans-4-aminocyclohexanecarboxylic acid esters and subsequent deblocking gave the cis- and trans- sarcolysylaminocyclohexanecarboxylates I (R = H, Et). Condensation of sarcolysin benzyl ester with cis- and trans-4-(benzyloxycarbonylamino)cyclohexancarboxylate and subsequent deblocking gave the cis- and trans-N-(cyclohexylcarbonyl)sarcolysins II.

After consulting a lot of data, we found that this compound(3685-23-2)Quality Control of cis-4-Aminocyclohexane carboxylic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Recommanded Product: 3-Methyl-1H-pyrrole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Direct Synthesis of Bipyrroles Using Phenyliodine Bis(trifluoroacetate) with Bromotrimethylsilane. Author is Dohi, Toshifumi; Morimoto, Koji; Maruyama, Akinobu; Kita, Yasuyuki.

Bipyrroles and a biindole are prepared regioselectively by oxidative dimerization of pyrroles or indoles with phenyliodine bis(trifluoroacetate) (PIFA) in the presence of bromotrimethylsilane. 3,4-Disubstituted pyrroles and 4,5,6,7-tetrahydroisoindole undergo dimerization to give 2,2′-bipyrroles (or 4,4′,5,5′,6,6′,7,7′-octahydro-1,1′-biisoindole) in 60-78% yields (with respect to PIFA). 3-Substituted-1H-pyrroles undergo regioselective oxidative dimerization with PIFA and bromotrimethylsilane to give 3,4′-disubstituted-2,2′-bipyrroles as the major products in 52-82% yields along with varying amounts of the 3,3′-disubstituted-2,2′-bipyrroles. 3-Methylindole undergoes oxidative dimerization to give 3,3′-dimethyl-2,2′-biindole in 74% yield in addition to 29% of 2-(3-methyl-1-indolyl)-3-methylindoline. While pyrrole undergoes oxidative dimerization with PIFA and bromotrimethylsilane to give only 2,2′-bipyrrole in 78% yield, 1-phenylpyrrole reacts under similar conditions to give 1,1′-diphenyl-2,3′-bipyrrole in 56% yield.

After consulting a lot of data, we found that this compound(616-43-3)Recommanded Product: 3-Methyl-1H-pyrrole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate