Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of mono-, di-, tri- and tetracarboxy azaphthalocyanines as potential dark quenchers, published in 2011, which mentions a compound: 56413-95-7, Name is 5,6-Dichloropyrazine-2,3-dicarbonitrile, Molecular C6Cl2N4, Related Products of 56413-95-7.

Mono-, di-, tri- and tetracarboxy-substituted metal-free azaphthalocyanines (AzaPc) were synthesized from 5,6-bis(diethylamino)pyrazine-2,3-dicarbonitrile and 6-(5,6-dicyano-3-(diethylamino)pyrazin-2-ylamino)hexanoic acid using a statistical condensation approach. AzaPc bearing eight diethylamino peripheral substituents was also isolated from the mixture Anal. of the distribution of congeners in the statistical mixture using optimized HPLC method (Phenomenex Synergy RP Fusion column, acetonitrile/tetrahydrofuran/water (pH 5.5) 50:20:30) was performed. The anal. showed optimal ratios of starting materials to be 3:1 for AAAB, 1:3 for ABBB and 1:1 for AABB/ABAB types of the congeners. The distribution of the congeners corresponded well with calculated values indicating similar reactivity of both starting materials and no steric constraint between adjacent isoindole units in the AzaPc ring. All studied AzaPc showed no fluorescence, extremely low singlet oxygen quantum yields (Φ Δ < 0.005) in monomeric form and strong absorption in a wide range from 300 nm to almost 700 nm. Such properties are highly promising for future study of these compounds as dark quenchers of fluorescence in DNA hybridization probes. After consulting a lot of data, we found that this compound(56413-95-7)Related Products of 56413-95-7 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56413-95-7, is researched, SMILESS is N#CC1=NC(Cl)=C(Cl)N=C1C#N, Molecular C6Cl2N4Journal, Journal of Photochemistry and Photobiology, A: Chemistry called Synthesis and comparison of photodynamic activity of alkylheteroatom substituted azaphthalocyanines, Author is Zimcik, Petr; Miletin, Miroslav; Kostka, Miroslav; Schwarz, Jan; Musil, Zbynek; Kopecky, Kamil, the main research direction is synthesis photodynamic activity alkyl heteroatom substitution azaphthalocyanine.Synthetic Route of C6Cl2N4.

Optimal reaction conditions were developed for synthesis of octakis(butylamino), octakis(butylsulfanyl) and octakis(butoxy) azaphthalocyanines (AzaPc’s) with central metal Mg, Zn and metal-free. Their photodynamic activity was measured and compared as a dye-sensitized photooxidation of 1,3-diphenylisobenzofuran (DPBF). Compounds with alkylamino substituent are very poor producers of the singlet oxygen and therefore not suitable as sensitizers for photodynamic therapy (PDT). On the other hand, compounds with alkylsulfanyl and alkoxy substituents possess very good photodynamic activity and are suitable for PDT.

After consulting a lot of data, we found that this compound(56413-95-7)Synthetic Route of C6Cl2N4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Application In Synthesis of 3-Methyl-1H-pyrrole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Sensory and Instrumental Analyses of Volatiles Generated during the Extrusion Cooking of Oat Flours. Author is Parker, Jane K.; Hassell, Glynis M. E.; Mottram, Donald S.; Guy, Robin C. E..

Three batches of oats were extruded under four combinations of process temperature (150 or 180°C) and process moisture (14.5 and 18%). Two of the extrudates were evaluated by a sensory panel, and three were analyzed by GC-MS. Maillard reaction products, such as pyrazines, pyrroles, furans, and sulfur-containing compounds, were found in the most severely processed extrudates (high-temperature, low-moisture). These extrudates were also described by the assessors as having toasted cereal attributes. Lipid degradation products, such as alkanals, 2-alkenals, and 2,4-alkadienals, were found at much higher levels in the extrudates of the oat flour that had been debranned. It contained lower protein and fiber levels than the others and showed increased lipase activity. Extrudates from these samples also had significantly lower levels of Maillard reaction products that correlated, in the sensory anal., with terms such as stale oil and oatmeal. Linoleic acid was added to a fourth oat flour to simulate the result of increased lipase activity, and GC-MS anal. showed both an increase in lipid degradation products and a decrease in Maillard reaction products.

After consulting a lot of data, we found that this compound(616-43-3)Application In Synthesis of 3-Methyl-1H-pyrrole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Molecular orbital treatment of a new type of heteroaromatic compound》. Authors are Brown, R. D.; Coller, B. A. W..The article about the compound:3-Methyl-1H-pyrrolecas:616-43-3,SMILESS:CC1=CNC=C1).Electric Literature of C5H7N. Through the article, more information about this compound (cas:616-43-3) is conveyed.

I, II, III, and IV are treated; of these only II is known (Boeckelheide and Windgassen, C.A. 52, 16355i). The present results indicate that all 4 compounds would be stable once formed. Resonance energies, π-electron d., and energies of excited states are given as a function of the electronegativity of N. Definite predictions of the position of highest reactivity toward electrophiles can be made for I and II; it is position 1 in either case.

After consulting a lot of data, we found that this compound(616-43-3)Electric Literature of C5H7N can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Recommanded Product: 5,6-Dichloropyrazine-2,3-dicarbonitrile. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about The synthesis and characterization of metal-free, unsymmetrical azaphthalocyanines with hydroxy groups and their complex formation with pyridine. Author is Kopecky, Kamil; Zimcik, Petr; Novakova, Veronika; Miletin, Miroslav; Musil, Zbynek; Stribna, Jana.

Three, unsym. metal-free azaphthalocyanines (AzaPc) were prepared using the statistical condensation of 5,6-bis(diethylamino)-pyrazine-2,3-dicarbonitrile (A) and the pyrazinedicarbonitrile (B) substituted with alkylamine chains bearing one or two hydroxy groups. The desired AAAB type, metal-free compounds were isolated, purified and characterized; the compounds contain one or two hydroxy groups that can be modified with suitable ligands. The mechanism leading to the unusual formation of a new morpholine ring during the preparation of some pyrazinedicarbonitriles is explained. Metal-free AzaPcs form a proton-transfer complex with two mols. of pyridine, this complex formation being accompanied by a change of solution color from purple to blue. The complex is formed directly with two mols. of pyridine, one on either side of the macrocycle. The rate constants of this process were found to be of the order ∼10-4 s-1; the rate of complex formation was not the same for all compounds and may depend on the AzaPc structure. The influence of hydroxy groups on the rate constant was not confirmed.

Although many compounds look similar to this compound(56413-95-7)Recommanded Product: 5,6-Dichloropyrazine-2,3-dicarbonitrile, numerous studies have shown that this compound(SMILES:N#CC1=NC(Cl)=C(Cl)N=C1C#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Segal, Menahem; Sims, Kenneth; Maggiora, Linda; Smissman, Edward published an article about the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O ).Application of 3685-23-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3685-23-2) through the article.

The response of hippocampal neurons to iontophoretic application of aminocyclohexanecarboxylic acid analogs of GABA in the presence of 0.5M acetylcholine or 15mM bicuculline showed that a precise spatial separation of the NH2 and CO2H groups was necessary to mimic the physiol. effects of GABA.

Although many compounds look similar to this compound(3685-23-2)Application of 3685-23-2, numerous studies have shown that this compound(SMILES:N[C@H]1CC[C@H](CC1)C(O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Electric Literature of C7H13NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis and antitumor activity of nonsymmetric phosphoric acid triamides. Author is Kosykhova, L.; Palaima, A.; Stumbryavichyute, Z..

R1R2P(O)NHR3 (R1, R2 independently = aziridino, N(CH2CH2Cl)2, NMe2, morpholino or NHCH2CH2OH; R3 = 4-R-substituted cyclohexyl (R = H, cis- and trans-CO2H, cis- and trans-CO2Et)) were prepared and tested for acute toxicity and antitumor activity. All the 12 tested compounds possess a lower antitumor activity as compared to that of the reference drug thiophosphamide. The antitumor activity of nonsym. phosphoric acid triamides is determined for the most part by the nature of amide residues attached at the P atom. The antitumor effect can be varied within a broad range by changing this residue, the maximum antitumor activity being inherent in nonsym. triamides containing the ethylenimine residue.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Syntheses and spectral properties of new dicyanopyrazine-related heterocycles from diaminomaleonitrile.SDS of cas: 56413-95-7.

New dicyanopyrazine-related heterocycles such as quinoxalines, furopyrazines, pyrrolopyrazines, and pyrazinoporphyrazines were synthesized and their absorption and fluorescence spectra were correlated with their structures.

Although many compounds look similar to this compound(56413-95-7)SDS of cas: 56413-95-7, numerous studies have shown that this compound(SMILES:N#CC1=NC(Cl)=C(Cl)N=C1C#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Reaction of 2,3-dichloro-5,6-dicyanopyrazine with amines.Recommanded Product: 5,6-Dichloropyrazine-2,3-dicarbonitrile.

Reaction of 2,3-dichloro-5,6-dicyanopyrazine (I) with amines gave mono-substituted or bis-substituted products (II; R1 = NH2, NHMe, NEt2, NMe2, pyrrolidino, morpholino; R2 = Cl, NH2, NHMe, NEt2, NHBu). Reaction if I with thioacetamide or 2,3-bis(N-methylamino)-5,6-dicyanopyrazine gave 1,4,6,9-tetraaza-2,3,7,8-tetracyanothianthrene or 2,3,7,8-tetracyano-1,4,6,9-tetraaza-5,10-dimethyl-5,10-dihydrophenazine, resp. Nonlinear optical properties for II as well as biol. activity of 2-[2-(diethylamino)vinyl]-3-chloro-5,6-dicyanopyrazine were evaluated.

Although many compounds look similar to this compound(56413-95-7)Recommanded Product: 5,6-Dichloropyrazine-2,3-dicarbonitrile, numerous studies have shown that this compound(SMILES:N#CC1=NC(Cl)=C(Cl)N=C1C#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Snyder, Kristin R.; Murray, Thomas F.; DeLander, Gary E.; Aldrich, Jane V. researched the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ).Reference of cis-4-Aminocyclohexane carboxylic acid.They published the article 《Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogs containing cis- and trans-4-aminocyclohexanecarboxylic acid》 about this compound( cas:3685-23-2 ) in Journal of Medicinal Chemistry. Keywords: conformationally constrained dynorphin A amide; aminocyclohexanecarboxylic acid dynorphin kappa opioid; structure activity opioid dynorphin A. We’ll tell you more about this compound (cas:3685-23-2).

4-Aminocyclohexanecarboxylic acid (I) was synthesized by catalytic hydrogenation of p-aminobenzoic acid, and the cis and trans isomers were separated by fractional recrystallization Analogs of dynorphin A(1-13)amide containing cis- and trans-I were prepared by solid-phase peptide synthesis using the 9-fluorenylmethoxycarbonyl (Fmoc) chem. protocol. Results from radioligand binding assays indicated that the peptides have modest affinity for κ opioid receptors and modest κ-receptor selectivity. These analogs containing cis- and trans-I are the first reported dynorphin A analogs constrained in the message sequence that are selective for κ receptors. The analog containing cis-I showed very weak opioid activity in the guinea pig ileum.

Although many compounds look similar to this compound(3685-23-2)Reference of cis-4-Aminocyclohexane carboxylic acid, numerous studies have shown that this compound(SMILES:N[C@H]1CC[C@H](CC1)C(O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate