This type of reactivity has quickly become one of the cornerstones of modern catalysis .In a patent, Product Details of 19132-06-0, name is (2S,3S)-Butane-2,3-diol, belongs to chiral-oxygen-ligands compound, introducing its new discovery. Product Details of 19132-06-0
Regio-, Diastereo-, and Enantioselective Synthesis of Vicinal Diols via alpha-Silyl Ketones
A new versatile and efficient regio-, diastereo-, and enantioselective synthesis of vicinal diols s-trans-4, s-trans-5, and s-cis-4 is described.Symmetrical ketones are converted into their SAMP- or RAMP-hydrazones which are then silylated with (isopropyloxy)dimethylsilyl chloride, followed by ozonolysis to afford the alpha-silyl ketones (R)-2 of high enantiomeric purity (ee 90 > 98percent).On the other hand, methyl ketones, after conversion into the corresponding (-)-(S)-1-amino-2-(methoxymethyl)pyrrolidine (SAMP) hydrazones, are silylated and then alkylated with R1 to afford unsymmetrical alpha-silyl ketones (S)-3 of high enantiomeric purity (ee 90->98percent).The reduction of the above obtained alpha-silyl ketones with L-Selectride, followed by oxidative cleavage of the C-Si bond gives rise to s-trans-4, s-trans-5, and s-cis-4 with high diastereoselectivity (de 95->98percent) and without racemization (ee >90->98percent).
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Product Details of 19132-06-0, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 19132-06-0
Reference：
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate