Reference of 538-58-9, Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 538-58-9 In a document type is Article, and a compound is mentioned, 538-58-9, Name is 1,5-Diphenylpenta-1,4-dien-3-one, introducing its new discovery.
Highly diastereo- and enantioselective iodoamination of chalcones, 4-aryl-4-oxobutenoates, and a trifluoro-substituted enone has been accomplished in the presence of a chiral N,N?-dioxide/[Sc(OTf)3] complex (0.5-2 mol%), delivering the desired vicinal anti-alpha-iodo-beta-amino carbonyl compounds regioselectively in high yields (up to 97%) and with excellent diastereoselectivities (>99:1 d.r.) and enantioselectivities (up to 99% ee). Enantiopure syn-alpha-iodo-beta-amino products could also be obtained from the isomerization of particular iodo compounds. TsNHX species (X=Cl, Br, I), generated from the reactions between the halo sources and TsNH2, were further confirmed as the active species in the haloamination reactions involved in the formation of the key halonium ion intermediates. A typical haloamination dependency was observed, with reactivity decreasing in the order NBS>NIS?NCS.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Reference of 538-58-9. I hope my blog about 538-58-9 is helpful to your research.
Reference：
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate