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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-4-Aminocyclohexane carboxylic acid(SMILESS: N[C@H]1CC[C@H](CC1)C(O)=O,cas:3685-23-2) is researched.Product Details of 56413-95-7. The article 《Increasing p-type dye sensitised solar cell photovoltages using polyoxometalates》 in relation to this compound, is published in Physical Chemistry Chemical Physics. Let’s take a look at the latest research on this compound (cas:3685-23-2).

Lindqvist polyoxometalate (POM) additives increase VOC in p-type DSSCs by up to 140%, yielding substantial efficiency gains for poorly matched dyes and redox mediators. For better dye/electrolyte combinations, these gains are typically outweighed by losses in JSC. Charge lifetime and transient IR measurements show that this is due to retardation of both recombination and electron transfer to the mediator, and a pos. shift in the NiO valence band edge. The POMs also show their own, limited sensitizing effect.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Hydrogenation of ammonium p-aminobenzoate on ruthenium and rhodium catalysts, the main research direction is catalytic hydrogenation ammonium aminobenzoate; benzoate amino ammonium hydrogenation; ruthenium catalysis aminobenzoate hydrogenation; rhodium catalysis aminobenzoate hydrogenation.Synthetic Route of C7H13NO2.

The rate of hydrogenation of aqueous p-H2NC6H4CO2- NH4+ in the presence of 10% Rh/C exceeded that in the presence of 10% Ru/C or 9.5% Ru-0.5% Pd/C, and increased linearly with the pressure at 40-100 atm; the apparent activitation energy at 80-150° was 9-10 kcal/mole. The combined yield of cis- (I) and trans-4-amino-1-cyclohexanecarboxylic acid (II) was 92-3% at 80° and 80 atm, but decreased with increasing temperature owing to thermal decomposition; the II-I ratio was independent of pressure, but increased with the hydrogenation temperature, owing to cis-trans isomerization.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Evaluation of the β-turn-inducing properties of an analog of (amino)piperidinonecarboxylates, the main research direction is beta turn mimetic acetylamino cyclohexanecarboxamide preparation.Name: cis-4-Aminocyclohexane carboxylic acid.

Cis-4-(Acetylamino)-N-(methyl)cyclohexanecarboxamide has been selected as all carbon ring analog of previously described 5-(amino)piperidinone-2-carboxylate systems. The potential β-turn-inducing properties of this model compound are evaluated by means of NMR anal. and mol. modeling. It was found that suitable as β-turn-inducing scaffold. Apparently, the planar lactam function in the native (amino)(oxo)piperidinecarboxylate systems is important to impose a correct conformation for β-turn induction.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Brain Research called Effects of some conformationally restricted GABA analogs on GABA membrane binding and nerve ending transport, Author is Hitzemann, Robert J.; Loh, Horace H., which mentions a compound: 3685-23-2, SMILESS is N[C@H]1CC[C@H](CC1)C(O)=O, Molecular C7H13NO2, Electric Literature of C7H13NO2.

By using a series of aminocyclopentane- and aminocyclohexanecarboxylic acids, as well as some naturally occurring amino acids, it was possible to determine some aspects of the spatial topog. of the GABA [56-12-2] membrane binding and transport sites in the rat brain. The Na-independent GABA binding site had a different spatial topog. than the Na-dependent binding site in that (±)-trans-3-aminocyclopentanecarboxylic acid (I) [19297-28-0] was 7-fold more potent than (±)-cis-3-aminocyclopentanecarboxylic acid (II) [49805-32-5] in inhibiting Na-independent binding, but only 1.6 times more potent in inhibiting Na-dependent binding. The nerve ending GABA transport site was similar to the Na-dependent GABA binding site in that it accommodated both I and II. However, the transport site differed from the binding site in that II was a potent inhibitor of transport but a weak inhibitor of binding. In addition to the differences in spatial characteristics, differences in the subcellular distribution of Na-independent and Na-dependent binding sites were observed The former were found primarily in the nerve ending-mitochondrial fraction, whereas the latter were primarily found in the microsomal fraction.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists, the main research direction is indolylazabicyclooctylmethylcyclohexyl dichlorocinnamamide preparation CCR2B receptor antagonist.Product Details of 3685-23-2.

The preparation and biol. evaluation of a series of indolopiperidine CCR2B receptor antagonists possessing a conformationally restricted C-5 linker chain in combination with a restricted piperidine ring are described. Compared to the parent compound, the analog I shows a dramatic improvement in selectivity against a range of 5-HT and dopaminergic receptors.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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Application of 3685-23-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis and biological study of bis(2-chloroethyl) sulfides containing carboxylic groups. 3. Cyclohexylamides of 3(or 4)-chloro-4(or 3)-[(2-chloroethyl)thio]butanoic acids. Author is Rasteikiene, L.; Vektariene, A.; Pociute, N.; Mikulskiene, G.; Valaviciene, J..

Cyclohexylamides Cl(CH2)2SCH(CH2Cl)CH2CONHC6H10R and Cl(CH2)2SCH2CHClCH2CONHC6H10R-4 (C6H10 = cyclohexane moiety, R = H, cis- or trans-CO2H, or -CH2CO2H, cis-β-substituted-DL-Ac-β-Ala-OH) were prepared by addition reaction of butenamides with Cl(CH2)2SCl. The biol. assay shows that the products are less toxic than analogous acids or phenylamides, whereas their antitumor effect remains high.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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Quality Control of cis-4-Aminocyclohexane carboxylic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Proton NMR spectroscopic study of the stereoconfiguration and conformation of cis and trans isomers of 3- and 4-aminocyclohexylalkanoic acids. Author is Palaima, A.; Staniulyte, Z.; Juodvirsis, A..

1H NMR spectral data for cyclohexane H1, H3 or H1, H4 protons of cis- and trans-3- and 4-aminocyclohexanealkanoic acids were successfully used for determination of the stereoconfigurations and conformational equilibrium of sep. isomers and for determination of cis/trans ratio in their mixtures by using Pr(NO3)3 and Eu(fod)3 as shift-reagents. For that purpose NMR data of the alkanoic substituents of the cyclohexane ring can also be used.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry called Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT), Author is Ding, Yun; Belyanskaya, Svetlana; DeLorey, Jennifer L.; Messer, Jeffrey A.; Joseph Franklin, G.; Centrella, Paolo A.; Morgan, Barry A.; Clark, Matthew A.; Skinner, Steven R.; Dodson, Jason W.; Li, Peng; Marino, Joseph P. Jr.; Israel, David I., which mentions a compound: 3685-23-2, SMILESS is N[C@H]1CC[C@H](CC1)C(O)=O, Molecular C7H13NO2, Related Products of 3685-23-2.

Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease. Inhibitors based on 1,3,5-triazine chemotype were discovered through affinity selection against two triazine-based DNA-encoded libraries. The structure and activity relationship study led to the expansion of the original 1,4-cycloalkyl series to related aniline, piperidine, quinoline, aryl-ether and benzylic series. The 1,3-cycloalkyl chemotype led to the discovery of a clin. candidate (GSK2256294, I) for COPD.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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Recommanded Product: 3685-23-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Reductive cyclization of aminobenzoic acids. Author is Augustine, Robert L.; Vag, Linda A..

Hydrogenation of m- and p-H2NC6H4CO2H over a Ru catalyst at 150°/1600 psig gave the bicyclic lactams I and II, resp. Cyclization also occurred on hydrogenation of 3,4-Me(H2N)C6H3CO2H. Hydrogenation of 3,4-(H2N)2C6H3CO2H resulted in loss of one of the NH2 groups; the 4-NH2 group was lost twice as readily as the 3-NH2 group. With 3,4-(HO)(H2N)C6H3CO2H, complete hydrogenolysis of the NH2 group occured.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

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Product Details of 3685-23-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Approaches towards the synthesis of fluoro(cyclo)alkylamines. Author is Windhorst, A. D.; Bechger, L.; Visser, G. W. M.; Menge, W. P. M. B.; Leurs, R.; Timmerman, H.; Herscheid, J. D. M..

The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane, 1-amino-7-fluoroheptane, cis/trans-4-fluorocyclohexylamine and cis-4-fluoromethylcyclohexylamine has been investigated for use as synthons for histamine receptor ligands for use in PET.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate