Category: chiral-oxygen-ligands

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile(SMILESS: N#CC1=NC(Cl)=C(Cl)N=C1C#N,cas:56413-95-7) is researched.Application of 400801-74-3. The article 《Crystalline salts of the ring-reduced tin(IV) dichloride hexadecachlorophthalocyanine and octachloro- and octacyanotetrapyrazinoporphyrazine macrocycles with strong electron-withdrawing ability》 in relation to this compound, is published in Dyes and Pigments. Let’s take a look at the latest research on this compound (cas:56413-95-7).

Substituted tin(IV) dichloride phthalocyanine and tetrapyrazinoporphyrazines with acceptor chloro- or cyano-substituents: SnIVCl2(PcCl16), SnIVCl2(TPyzPzCl8) and SnIVCl2{TPyzPz(CN)8}, where PcCl16 = hexadecachlorophthalocyanine; TPyzPz(CN)8 = octacyanotetrapyrazinoporphyrazine, TPyzPzCl8 = octachlorotetrapyrazinoporphyrazine were synthesized. The reduction of these metallomacrocycles by fullerene {cryptand(Na+)}(C•-60) salt (1, 3 and 4) or potassium graphite (KC8) in the presence of cryptand (2) yields crystalline anionic salts: {cryptand(Na+)}2[SnIVCl2(PcCl4-16)]2-·C6H4Cl2 (1), {cryptand(K+)}2[{SnII(PcCl4-16)}0.926{SnIVCl2(PcCl4-16)}0.074]2-·2C6H4Cl2 (2), {cryptand(Na+)}[SnIVCl2{TPyzPz(CN)•3-8}]•-·C6H4Cl2 (3) and {cryptand(Na+)}2[SnIVCl2(TPyzPzCl4-8)]2-·2C6H4Cl2 (4). Reduction of SnIVCl2(macrocycle2-) with dianion macrocycles is accompanied by the formation of radical trianion or tetraanion macrocycles in 1-4. As stronger reductant, KC8 reduces the macrocycle and in addition nearly complete metal centered reduction from tin(IV) to tin(II) took place. Strong blue shift of the Q-band and new absorption bands are observed in the NIR range in the spectra of 1-4. Partial disruption of macrocycle aromaticity and alternation of the C – Nmeso bonds were found for the reduced macrocycles. Macrocycles are planar, and SnIV atoms are positioned exactly in the macrocycle plane. The only exception is strong distortion of the PcCl16 macrocycle in SnII(PcCl4-16) (2). Structures of 1-4 contain layers from the macrocycles having the side-by-side contacts in 1, 2, 4 and separated by cationic layers. Salt 3 presents the first structure of the TPyzPz(CN)8 macrocycle with strongest acceptor properties among known porphyrins and porphyrazines. It was shown that tetraanion macrocycles are diamagnetic in 1, 2 and 4. The [SnIVCl2{TPyzPz(CN)8•3-}]•- radical anions are paramagnetic in 3 with effective magnetic moment of 1.64μB, and salt 3 shows moderate antiferromagnetic coupling of spins with Weiss temperature of -14 K.

Although many compounds look similar to this compound(56413-95-7)Application of 56413-95-7, numerous studies have shown that this compound(SMILES:N#CC1=NC(Cl)=C(Cl)N=C1C#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Electric Literature of C6Cl2N4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Syntheses and Langmuir-Blodgett film formation of donor-acceptor molecules. Author is Zhu, Daoben; Yang, Chun; Liu, Yunqi; Xu, Yu.

Several novel organic mols. with donor-acceptor structure were designed and synthesized as non-linear optical (NLO) materials. Stable Langmuir films were formed at the air-water interface. Under appropriate exptl. conditions monolayers of these mols. were deposited in a Z-type mode. The Langmuir-Blodgett (LB) films were characterized by UV-visible spectroscopy, SEM and low-angle x-ray diffraction measurement. The NLO behavior of their monolayers was evaluated from second harmonic generation (SHG).

Although many compounds look similar to this compound(56413-95-7)Electric Literature of C6Cl2N4, numerous studies have shown that this compound(SMILES:N#CC1=NC(Cl)=C(Cl)N=C1C#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile(SMILESS: N#CC1=NC(Cl)=C(Cl)N=C1C#N,cas:56413-95-7) is researched.Electric Literature of C6Cl2N4. The article 《Cationic azaphthalocyanines bearing aliphatic tertiary amino substituents-Synthesis, singlet oxygen production and spectroscopic studies》 in relation to this compound, is published in Journal of Photochemistry and Photobiology, A: Chemistry. Let’s take a look at the latest research on this compound (cas:56413-95-7).

New cationic zinc azaphthalocyanines (AzaPc) were prepared using a statistical method of synthesis starting from 5,6-bis(2-diethylaminoethylsulfanyl)pyrazine-2,3-dicarbonitrile (A) and 5,6-bis(tert-butylsulfanyl)pyrazine-2,3-dicarbonitrile (B). All the six possible AzaPc derivatives were detected on TLC but only five of them were finally isolated using column chromatog. on silica (excluding AAAB type). The adjacent (AABB) and opposite (ABAB) isomers were well separated Singlet oxygen quantum yields (ΦΔ) were measured using the DPBF decomposition method. Values of ΦΔ in anhydrous DMF drastically decrease with the number of amino groups from 0.66 for BBBB type to 0.04 for AAAA type. The same dependence was observed in anhydrous DMF for the corresponding hydrochlorides. When DMF/water 95:5 added with HCl was used, the ΦΔ values for amino AzaPc increased to approx. 0.66. This suggests that solvation of the amino and Cl- ions plays an important role in the separation of the AzaPc mols. although no changes were found in UV-vis spectra. At least eight cationic charges are necessary for complete monomerization of AzaPc in water. Fewer charges lead to significant decrease of the absorption in the area of the Q-band and to pronounced dimeric character of the absorption spectrum.

Although many compounds look similar to this compound(56413-95-7)Application of 56413-95-7, numerous studies have shown that this compound(SMILES:N#CC1=NC(Cl)=C(Cl)N=C1C#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Application of 3685-23-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis and properties of 2-azabicyclo[2:2:2]octan-3-one and 6-azabicyclo[3:2:1]octan-7-one.

Optimal reaction conditions for the synthesis of lactams of cis-3- and -4-ACH acids and their derivatives were determined 1H NMR spectral data confirmed different configuration of lactams of cis-3- and cis-4-derivatives Possibility to apply lactams for the separation of cis- and trans-isomers was investigated.

Although many compounds look similar to this compound(3685-23-2)Application of 3685-23-2, numerous studies have shown that this compound(SMILES:N[C@H]1CC[C@H](CC1)C(O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Biancalana, Lorenzo; Bresciani, Giulio; Marchetti, Fabio; Pampaloni, Guido published an article about the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O ).SDS of cas: 3685-23-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3685-23-2) through the article.

The serendipitous discovery of the unprecedented route to a zwitterionic imidazolium mol. with the two nitrogen atoms substituted with 4-cyclohexanecarboxylic acid was reported. To build the five-membered ring, glyoxal played the double role of source for C2 and unusually C1 units, the latter via thermal decomposition afforded carbon monoxide as side-product. The product was characterized by elemental anal., multinuclear NMR, IR and ESI-MS spectroscopy.

Although many compounds look similar to this compound(3685-23-2)SDS of cas: 3685-23-2, numerous studies have shown that this compound(SMILES:N[C@H]1CC[C@H](CC1)C(O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Preparation and properties of ruthenium catalysts of the liquid-phase hydrogenation of aromatic compounds.Recommanded Product: 3685-23-2.

The activity and sp. surface of 5% Ru catalysts increased in the order of supports SiO2 < γ-Al2O3 < C, but the specific activity per m2 surface was independent of the support or the method of catalyst preparation A catalyst prepared by treating C with Ru(OH)Cl3 at pH 5.9-6.1 followed by reduction with H at 300° or NaBH4 at 20° had the highest dispersion and specific activity by weight of those studied in the hydrogenation of p-H2NC6H4CO2- NH4+ (p-I). Hexahydroarom. acids were formed in 86-98% yield from m- and p-I, p-H2NCH2C6H4CO2- NH4+, p-Me3CC6H4CO2Na, ammonium isonicotinate and BzOH, and acenaphthene gave >90% perhydroacenaphthene at 80-145° and 60-80 atm.

Compounds in my other articles are similar to this one(cis-4-Aminocyclohexane carboxylic acid)Recommanded Product: 3685-23-2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3685-23-2, is researched, SMILESS is N[C@H]1CC[C@H](CC1)C(O)=O, Molecular C7H13NO2Journal, Article, Bioorganic & Medicinal Chemistry called Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT), Author is Ding, Yun; Belyanskaya, Svetlana; DeLorey, Jennifer L.; Messer, Jeffrey A.; Joseph Franklin, G.; Centrella, Paolo A.; Morgan, Barry A.; Clark, Matthew A.; Skinner, Steven R.; Dodson, Jason W.; Li, Peng; Marino, Joseph P. Jr.; Israel, David I., the main research direction is soluble epoxide hydrolase inhibitor GSK2256294 DNA encoded library; DNA-encoded library technology; Soluble epoxide hydrolase.COA of Formula: C7H13NO2.

Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease. Inhibitors based on 1,3,5-triazine chemotype were discovered through affinity selection against two triazine-based DNA-encoded libraries. The structure and activity relationship study led to the expansion of the original 1,4-cycloalkyl series to related aniline, piperidine, quinoline, aryl-ether and benzylic series. The 1,3-cycloalkyl chemotype led to the discovery of a clin. candidate (GSK2256294, I) for COPD.

Compounds in my other articles are similar to this one(cis-4-Aminocyclohexane carboxylic acid)COA of Formula: C7H13NO2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Synthetic Route of C5H7N. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about A Model Binding Site for Testing Scoring Functions in Molecular Docking. Author is Wei, Binqing Q.; Baase, Walter A.; Weaver, Larry H.; Matthews, Brian W.; Shoichet, Brian K..

Prediction of interaction energies between ligands and their receptors remains a major challenge for structure-based inhibitor discovery. Much effort has been devoted to developing scoring schemes that can successfully rank the affinities of a diverse set of possible ligands to a binding site for which the structure is known. To test these scoring functions, well-characterized exptl. systems can be very useful. Here, mutation-created binding sites in T4 lysozyme were used to investigate how the quality of at. charges and solvation energies affects mol. docking. At. charges and solvation energies were calculated for 172,118 mols. in the Available Chems. Directory using a semi-empirical quantum mech. approach by the program AMSOL. The database was first screened against the apolar cavity site created by the mutation Leu99Ala (L99A). Compared to the electronegativity-based charges that are widely used, the new charges and desolvation energies improved ranking of known apolar ligands, and better distinguished them from more polar isosteres that are not observed to bind. To investigate whether the new charges had predictive value, the non-polar residue Met102, which forms part of the binding site, was changed to the polar residue glutamine. The structure of the resulting Leu99 Ala and Met102 Gln double mutant of T4 lysozyme (L99A/M102Q) was determined and the docking calculation was repeated for the new site. Seven representative polar mols. that preferentially docked to the polar vs. the apolar binding site were tested exptl. All seven bind to the polar cavity (L99A/M102Q) but do not detectably bind to the apolar cavity (L99A). Five ligand-bound structures of L99A/M102Q were determined by X-ray crystallog. Docking predictions corresponded to the crystallog. results to within 0.4 A RMSD. Improved treatment of partial at. charges and desolvation energies in database docking appears feasible and leads to better distinction of true ligands. Simple model binding sites, such as L99A and its more polar variants, may find broad use in the development and testing of docking algorithms.

Compounds in my other articles are similar to this one(3-Methyl-1H-pyrrole)Synthetic Route of C5H7N, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

COA of Formula: C6Cl2N4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Dually directional glycosylated phthalocyanines as extracellular red-emitting fluorescent probes. Author is Husain, Ali; Ganesan, Asaithampi; Machacek, Miloslav; Cerveny, Lukas; Kubat, Pavel; Ghazal, Basma; Zimcik, Petr; Makhseed, Saad.

The development of new non-aggregated phthalocyanines bearing multivalent saccharide moieties on their macrocyclic rims is of great interest. Many characteristics, including water-solubility, non-toxicity and others, can be feasibly obtained by these amphiphiles which can be considered as a key solution for demonstrating highly efficient photoactive materials in water. Herein, a family of five newly prepared dually directional Zn(II) containing phthalocyanines (PcG1-4) and azaphthalocyanine (AzaPcG1) glycoconjugates is described. The unique spatial arrangement of the glucoside units based on peripherally hexadeca-(PcG1) and nonperipherally octa-(PcG4) macrocycles provides a fully monomeric behavior along with a high fluorescence (ΦF ~0.21) in aqueous solution These amphiphiles were characterized by low toxicity, and an extremely low cellular uptake was obtained due to the highly polar nature of the glucoside substituents. Accordingly, their potential as suitable photoactive chromophores for red-emitting extracellular fluorescent probes has been confirmed upon the evaluation of paracellular transport using a layer of MDCKII cells with the permeability coefficient fully comparable with an established evaluator of the integrity of the monolayer.

Compounds in my other articles are similar to this one(5,6-Dichloropyrazine-2,3-dicarbonitrile)COA of Formula: C6Cl2N4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Functional dyes derived from 2,3-dichloro-5,6-dicyanopyrazine, the main research direction is cyanopyrazine dye synthesis nucleophilic substitution; amine nucleophilic substitution dichlorodicyanopyrazine.Category: chiral-oxygen-ligands.

Chlorine nucleophilic substitution of 2,3-dichloro-5,6-dicyanopyrazine (I) with amines yielded 8 mono- or disubstituted derivatives that were tested for their second harmonic generation (SHG) and biol. activity. Triethylamine reaction with I gave a new enamine product that was characterized by NMR and IR spectroscopy. Effectiveness in controlling some plant diseases was observed

Compounds in my other articles are similar to this one(5,6-Dichloropyrazine-2,3-dicarbonitrile)Category: chiral-oxygen-ligands, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate