Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Ellis, Martin K. and a compound is mentioned, 4254-15-3, (S)-Propane-1,2-diol, introducing its new discovery. 4254-15-3
Attempted Kinetic Resolution of 1,2-Diols by Camphorquinone: Generation of (R)-(Chloromethyl)oxirane
The epichlorohydrin (R)-(chloromethyl)oxirane has been prepared from rac-3-chloropropane-1,2-diol by means of the chiral ketone D-camphorquinone (1,7,7-trimethylbicyclo<2.2.1>heptane-2,3-dione).These reactions lead to intermediate dioxolanes which can be converted directly into oxiranes.This conversion was effected by reduction of the C-2-ketone of the dioxolane intermediate with sodium borohydride prior to reaction with hydrogen bromide-acetic acid followed by treatment of the resulting acetoxy bromide with sodium ethane-1,2-diolate.The diastereoselective formation of other dioxolanes was also investigated by reaction of D-camphorquinone with ethane-1,2-diol, propane-1,2-diol, and 3,3-dimethylbutane-1,2-diol.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 2412-58-0!, 4254-15-3
Reference£º
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate