Chiral oxygen ligands

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56413-95-7, is researched, Molecular C6Cl2N4, about The synthesis and characterization of metal-free, unsymmetrical azaphthalocyanines with hydroxy groups and their complex formation with pyridine, the main research direction is azaphthalocyanine pyridine complex preparation dye.HPLC of Formula: 56413-95-7.

Three, unsym. metal-free azaphthalocyanines (AzaPc) were prepared using the statistical condensation of 5,6-bis(diethylamino)-pyrazine-2,3-dicarbonitrile (A) and the pyrazinedicarbonitrile (B) substituted with alkylamine chains bearing one or two hydroxy groups. The desired AAAB type, metal-free compounds were isolated, purified and characterized; the compounds contain one or two hydroxy groups that can be modified with suitable ligands. The mechanism leading to the unusual formation of a new morpholine ring during the preparation of some pyrazinedicarbonitriles is explained. Metal-free AzaPcs form a proton-transfer complex with two mols. of pyridine, this complex formation being accompanied by a change of solution color from purple to blue. The complex is formed directly with two mols. of pyridine, one on either side of the macrocycle. The rate constants of this process were found to be of the order ∼10-4 s-1; the rate of complex formation was not the same for all compounds and may depend on the AzaPc structure. The influence of hydroxy groups on the rate constant was not confirmed.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Biancalana, Lorenzo; Bresciani, Giulio; Marchetti, Fabio; Pampaloni, Guido researched the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ).Product Details of 3685-23-2.They published the article 《Serendipitous Formation of a Zwitterionic Imidazolium Molecule from α-Diimine with Glyoxal as Unusual Cyclization Agent》 about this compound( cas:3685-23-2 ) in ChemistrySelect. Keywords: bis carboxycyclohexyl imidazole preparation; aminocyclohexane carboxylic acid glyoxal cyclization. We’ll tell you more about this compound (cas:3685-23-2).

The serendipitous discovery of the unprecedented route to a zwitterionic imidazolium mol. with the two nitrogen atoms substituted with 4-cyclohexanecarboxylic acid was reported. To build the five-membered ring, glyoxal played the double role of source for C2 and unusually C1 units, the latter via thermal decomposition afforded carbon monoxide as side-product. The product was characterized by elemental anal., multinuclear NMR, IR and ESI-MS spectroscopy.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Methyl-1H-pyrrole(SMILESS: CC1=CNC=C1,cas:616-43-3) is researched.Quality Control of cis-4-Aminocyclohexane carboxylic acid. The article 《Computer program for calculating the nuclear magnetic double resonance spectrum》 in relation to this compound, is published in Hokkaido Daigaku Kogakubu Kenkyu Hokoku. Let’s take a look at the latest research on this compound (cas:616-43-3).

A computer program for simulating a NMR spectrum was developed based on the theory which takes the mixing of energy levels by the irradiating radio-frequency field into account. The program is applicable to all types of spin systems up to 6 spins with I = 1/2. It was successfully applied to the calculation of the double resonance spectrum of the N-H proton of 3-methylpyrrole.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Johnston, Thomas P.; McCaleb, George S.; Clayton, Sarah D.; Frye, Jerry L.; Krauth, Charles A.; Montgomery, John A. published the article 《Synthesis of analogs of N-(2-chloroethyl)-N’-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents》. Keywords: neoplasm inhibitor nitrosourea derivative configuration; anticancer chloroethylmethylcyclohexylnitrosourea analog configuration.They researched the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ).Quality Control of cis-4-Aminocyclohexane carboxylic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3685-23-2) here.

Of several nitrosourea derivatives [X(CH2)2N(NO)CONHR (X = Cl, F; R = substituted cyclohexyl, 2-methyl-1,3-dithian-5-yl or its S, S, S’, S’-tetraoxide)] prepared and tested against murine leukemia L210 almost all were active, giving cure rates ≥50% at ≤LD10 doses. In 4 of the 5 fluoroethyl analogs activity was clearly inferior to the corresponding chloroethyl compounds Most of the more active analogs contained a 4-substituted cyclohexyl group. Activity in relation to structure, partition coefficient, and cis-trans isomerism is discussed.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Recommanded Product: cis-4-Aminocyclohexane carboxylic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril. Author is Kaye, B.; Brearley, C. J.; Cussans, N. J.; Herron, M.; Humphrey, M. J.; Mollatt, A. R..

Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo in the mouse, rat, rabbit, dog and man. Oral doses of [14C]candoxatril were cleared rapidly, mostly by ester hydrolysis to candoxatrilat, in the mouse, dog and man. A complementary i.v. study in man with [14C]candoxatrilat showed that the active drug was virtually completely renally cleared. Neither candoxatril nor candoxatrilat underwent chiral inversion in man. The systemic availability of candoxatrilat from the oral prodrug was estimated to be 88, 53, 42, 17 and 32% in the mouse, rat, rabbit, dog and man resp. Plasma clearance of candoxatril was too rapid to enable pharmacokinetic parameter calculation in mice and rabbits; for man, the apparent oral clearance was 57.9 mL/min/kg and the elimination half-life was 0.46 h. For i.v. candoxatrilat, total plasma clearance values were 32, 15, 5.5, 5.8 and 1.9 mL/min/kg for the mouse, rat, rabbit, dog and man, resp. Renal clearance values were 8.7, 7.2, 2.9 and 1.7 mL/min/kg for the mouse, rat, dog and man, resp., and these approximated the resp. glomerular filtration rates. Allometric scaling with respect to body weight across the species allowed reasonable prediction of the above 2 clearance parameters in man.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cao, Jing-Pei; Zhao, Xiao-Yan; Morishita, Kayoko; Wei, Xian-Yong; Takarada, Takayuki researched the compound: 3-Methyl-1H-pyrrole( cas:616-43-3 ).Product Details of 616-43-3.They published the article 《Fractionation and identification of organic nitrogen species from bio-oil produced by fast pyrolysis of sewage sludge》 about this compound( cas:616-43-3 ) in Bioresource Technology. Keywords: organic nitrogen species bio oil pyrolysis sewage sludge pyrolysis. We’ll tell you more about this compound (cas:616-43-3).

Pyrolysis of sewage sludge was performed at 500° and a sweeping gas flow rate of 300 cm3/min in a drop tube furnace. Liquid fraction (i.e., bio-oil) from the sewage sludge pyrolysis was separated by silica-gel column chromatog. (SGCC) with different solvents, including mixed solvents, as eluants. Alkanenitriles (C13-C18), oleamide, alkenenitrile, fatty acid amides and aromatic nitrogen species were fractionated from the bio-oil by SGCC and analyzed with a gas chromatog./mass spectrometry (GC/MS). Most of the GC/MS-detectable organic nitrogen species (ONSs) are lactams, amides and N-heterocyclic compounds, among which acetamide is the most abundant. N-heterocyclics with 1-3 rings, including pyrrole, pyridine, indole, benzoimidazole, carbazole, norharman and harman, were observed The lactams detected include pyrrolidin-2-one, succinimide, phthalimide, glutarimide, piperidin-2-one and 3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione, all of which should be formed via decarboxylation and cyclization of γ- and δ-amino acids. Such a procedure provides an effective approach to fractionation and identification of ONSs from bio-oil produced by fast pyrolysis of sewage sludge.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril, published in 1997-10-31, which mentions a compound: 3685-23-2, mainly applied to candoxatril candoxatrilat pharmacokinetics species, Recommanded Product: 3685-23-2.

Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo in the mouse, rat, rabbit, dog and man. Oral doses of [14C]candoxatril were cleared rapidly, mostly by ester hydrolysis to candoxatrilat, in the mouse, dog and man. A complementary i.v. study in man with [14C]candoxatrilat showed that the active drug was virtually completely renally cleared. Neither candoxatril nor candoxatrilat underwent chiral inversion in man. The systemic availability of candoxatrilat from the oral prodrug was estimated to be 88, 53, 42, 17 and 32% in the mouse, rat, rabbit, dog and man resp. Plasma clearance of candoxatril was too rapid to enable pharmacokinetic parameter calculation in mice and rabbits; for man, the apparent oral clearance was 57.9 mL/min/kg and the elimination half-life was 0.46 h. For i.v. candoxatrilat, total plasma clearance values were 32, 15, 5.5, 5.8 and 1.9 mL/min/kg for the mouse, rat, rabbit, dog and man, resp. Renal clearance values were 8.7, 7.2, 2.9 and 1.7 mL/min/kg for the mouse, rat, dog and man, resp., and these approximated the resp. glomerular filtration rates. Allometric scaling with respect to body weight across the species allowed reasonable prediction of the above 2 clearance parameters in man.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Raman spectra of pyrroles and a few derivatives》. Authors are Stern, A.; Thalmayer, K..The article about the compound:3-Methyl-1H-pyrrolecas:616-43-3,SMILESS:CC1=CNC=C1).Application of 616-43-3. Through the article, more information about this compound (cas:616-43-3) is conveyed.

Raman spectra were obtained for pyrrole and the following derivatives, 3-Me; 2,3-di-Me; 2,4-di-Et; 2-Et; 2-Me-4-Et; 2,4-di-Me-3,5-di-Et; 2,4-di-Et-3-Pr; 2,4-di-Et-3-Me. In pure pyrrole, frequencies corresponding to CC and CN double-bond vibrations and those of the methylene group were detected. These had only been found previously in substituted pyrroles. This indicates that free pyrrole also contains some of the pyrrolinene form and the earlier model of the mol. as proposed by Bonino, Manzoni-Ansidei and Pratesi (cf. C. A. 28,5336.8) must be modified.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56413-95-7, is researched, SMILESS is N#CC1=NC(Cl)=C(Cl)N=C1C#N, Molecular C6Cl2N4Journal, Journal of Porphyrins and Phthalocyanines called Syntheses of Octa(dialkylamino)azaphthalocyanines, Author is Morkved, Eva H.; Kjosen, Helge; Ossletten, Hege; Erchak, Nikolai, the main research direction is azaphthalocyanine dialkylamino copper nickel preparation; transition metal dialkylamino azaphthalocyanine preparation; pyrazine diiminoimide cyclization dialkylamino azaphthalocyanine preparation.Product Details of 56413-95-7.

Ni(II) octa(4-morpholinyl)- (11a) and Cu(II) octa(1-pyrrolidinyl)- (11b) azaphthalocyanines were prepared from the corresponding pyrazine diiminoimides (10). The precursor pyrazine dicarbonitriles (2) gave 6-cyanopyrazine-5-alkyl carboximidates (3-9) as stable intermediates when reacted with NH3 and catalytic amounts of Na alkoxide in alcs. 3-9 Were converted to the diiminoimides 10 upon reflux in PrOH or BuOH for several hours. This unusual reaction pattern was observed for pyrazine-2,3-dicarbonitriles (2) with morpholine, thiomorpholine, piperidine or pyrrolidine substituted in the 5- and 6-positions.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Effects of Atractylodes Oil on Inflammatory Response and Serum Metabolites in Adjuvant Arthritis Rats.Application of 3685-23-2.

Atractylodes Rhizoma is one of two principal components in Ermiaosan, a well-known traditional Chinese medicine for the treatment of rheumatoid arthritis (RA). Atractylodes oil (AO) represents a potential alternative treatment for RA. The purpose of this study was to investigate the effect of AO in rats with Adjuvant Arthritis (AA) by exploration of changes in serum metabolites using gas chromatog.-mass spectrometry (GC-MS). Foot thickness and arthritis score, ankle joint pathol. structure, the concentrations of TNF-α, IL-1β, IL-6, IL-17 and the expression of MMPs in ankle joint tissue were measured as indicators of efficacy of treatment using AO. In addition, multivariate statistical anal. was used to identify differential production of metabolites and biomarkers, and to analyze metabolic pathways. The results demonstrate that administration of AO resulted in a good therapeutic effect in the AA rat model, with significantly improved joint swelling, reduced joint score, and inhibition of inflammation, synovial pannus hyperplasia, and bone and cartilage destruction. Furthermore, AO was found to exert its effect against rheumatoid arthritis principally by differentially affecting 11 metabolites and six metabolic pathways, predominantly related to abnormal amino acid metabolism, in addition to energy-related metabolic pathways. This study evaluated the capability of AO to effectively treat AA rats, providing a novel strategy for the treatment of RA.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate