Chiral oxygen ligands

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56413-95-7, is researched, Molecular C6Cl2N4, about Syntheses and spectral properties of new dicyanopyrazine-related heterocycles from diaminomaleonitrile, the main research direction is dicyanopyrazine precursor fluorescent dye synthesis; quinoxaline dye preparation dicyanopyrazine precursor; furopyrazine dye preparation dicyanopyrazine precursor; pyrrolopyrazine dye preparation dicyanopyrazine precursor; pyrazinoporphyrazine dye preparation dicyanopyrazine precursor.Quality Control of 5,6-Dichloropyrazine-2,3-dicarbonitrile.

New dicyanopyrazine-related heterocycles such as quinoxalines, furopyrazines, pyrrolopyrazines, and pyrazinoporphyrazines were synthesized and their absorption and fluorescence spectra were correlated with their structures.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 616-43-3, is researched, SMILESS is CC1=CNC=C1, Molecular C5H7NJournal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Direct Synthesis of Bipyrroles Using Phenyliodine Bis(trifluoroacetate) with Bromotrimethylsilane, Author is Dohi, Toshifumi; Morimoto, Koji; Maruyama, Akinobu; Kita, Yasuyuki, the main research direction is bipyrrole regioselective preparation; biindole regioselective preparation; regioselective oxidative dimerization pyrrole indole phenyliodonium trifluoroacetate bromotrimethylsilane.Formula: C5H7N.

Bipyrroles and a biindole are prepared regioselectively by oxidative dimerization of pyrroles or indoles with phenyliodine bis(trifluoroacetate) (PIFA) in the presence of bromotrimethylsilane. 3,4-Disubstituted pyrroles and 4,5,6,7-tetrahydroisoindole undergo dimerization to give 2,2′-bipyrroles (or 4,4′,5,5′,6,6′,7,7′-octahydro-1,1′-biisoindole) in 60-78% yields (with respect to PIFA). 3-Substituted-1H-pyrroles undergo regioselective oxidative dimerization with PIFA and bromotrimethylsilane to give 3,4′-disubstituted-2,2′-bipyrroles as the major products in 52-82% yields along with varying amounts of the 3,3′-disubstituted-2,2′-bipyrroles. 3-Methylindole undergoes oxidative dimerization to give 3,3′-dimethyl-2,2′-biindole in 74% yield in addition to 29% of 2-(3-methyl-1-indolyl)-3-methylindoline. While pyrrole undergoes oxidative dimerization with PIFA and bromotrimethylsilane to give only 2,2′-bipyrrole in 78% yield, 1-phenylpyrrole reacts under similar conditions to give 1,1′-diphenyl-2,3′-bipyrrole in 56% yield.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Application In Synthesis of cis-4-Aminocyclohexane carboxylic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors. Author is Ontoria, Jesus M.; Rydberg, Edwin H.; Di Marco, Stefania; Tomei, Licia; Attenni, Barbara; Malancona, Savina; Martin Hernando, Jose I.; Gennari, Nadia; Koch, Uwe; Narjes, Frank; Rowley, Michael; Summa, Vincenzo; Carroll, Steve S.; Olsen, David B.; De Francesco, Raffaele; Altamura, Sergio; Migliaccio, Giovanni; Carfi, Andrea.

The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells and, as a consequence, is an attractive target for inhibition. Herein, we present 1H-benzo[de]isoquinoline-1,3(2H)-diones as a new series of selective inhibitors of HCV NS5B polymerase. The HTS hit 1 shows submicromolar potency in two different HCV replicons (1b and 2b) and displays no activity on other polymerases (HIV-RT, Polio-pol, GBV-b-pol). These inhibitors act during the pre-elongation phase by binding to NS5B non-nucleoside binding site Thumb Site II as demonstrated by crystal structure of compound 1 with the ΔC55-1b and ΔC21-2b enzymes and by mutagenesis studies. SAR in this new series reveals inhibitors, such as 20, with low micromolar activity in the HCV replicon and with good activity/toxicity window in cells.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Dubinina, G. G.; Platonov, M. O.; Golovach, S. M.; Borysko, P. O.; Tolmachov, A. O.; Volovenko, Y. M. published the article 《Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity》. Keywords: pyrrolopyrazinedicarbonitrile substituted preparation inhibitor protein kinase mol modeling; anticancer pyrrolopyrazinedicarbonitrile preparation antiproliferative human cancer cell line.They researched the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ).SDS of cas: 56413-95-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56413-95-7) here.

New derivatives of pyrrolo[2,3-b]pyrazine were synthesized and tested on a panel of cultured human tumor cell lines. It was found that 6-amino-5-(3-chlorophenylamino)-7-(1-methyl-1H-benzo[d]imidazol-2-yl)-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitrile (I) exhibited a significant antiproliferative activity: GI50 for cell lines RXF 393 (renal cancer) and BT-549 (breast cancer) were 14 and 82 nM, resp. To identify possible mol. targets, docking of the most active compounds into the active sites of cyclin-dependent kinases was performed. Mol. modeling of the inhibitor-enzyme complexes showed the differences in the binding poses of new pyrrolo[2,3-b]pyrazine derivatives in the kinase ATP-binding site compared with known pyrrolo[2,3-b]pyrazine inhibitors called aloisines. The patterns of drug kinase interactions correlated well with antiproliferative activities of novel derivatives Key interactions and binding mode of docked compounds are discussed.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Related Products of 3685-23-2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Analysis of metabolites and metabolic mechanism in Bt transgenic and non-transgenic maize. Author is Zhang, Liyuan; Yu, Runzhong; Yu, Yingbo.

The gas chromatog.-mass spectrometry was used to isolate and identify metabolites of non-transgenic and Bacillus thuringiensis transgenic maize. The non-targeted metabolomics technique was used to anal. the metabolic pathway and mechanism of two kinds of maize. The methanol was used as extractant and the N,O-bis(trimethylsilyl) trifluoroacetamide was used as derivatization reagent. 38 kinds of metabolites were isolated and identified from non-transgenic maize, and 61 kinds of metabolites were isolated and identified in Bacillus thuringiensis transgenic maize. The specific metabolites between non-transgenic and Bacillus thuringiensis transgenic maize were analyzed. The metabolic pathway of specific metabolites was analyzed by KEGG annotation. The metabolic mechanism of non-transgenic maize and Bacillus thuringiensis transgenic maize was explored. The result indicated there were more metabolites involved in metabolic pathways in Bacillus thuringiensis transgenic maize than in non-transgenic maize, and tricarboxylic acid cycle and energy metabolism pathways of Bacillus thuringiensis transgenic maize are found to be higher than that of non-transgenic maize. The metabolic pathway of Bacillus thuringiensis transgenic maize conforms to the biol. activity law.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chow, Christopher W. K.; van Leeuwen, John A.; Fabris, Rolando; Drikas, Mary researched the compound: 3-Methyl-1H-pyrrole( cas:616-43-3 ).Recommanded Product: 616-43-3.They published the article 《Optimised coagulation using aluminium sulfate for the removal of dissolved organic carbon》 about this compound( cas:616-43-3 ) in Desalination. Keywords: aluminum sulfate dissolved organic carbon coagulation water treatment; reservoir water pollution natural organic matter coagulation. We’ll tell you more about this compound (cas:616-43-3).

Coagulation experiments at pH values ranging from 3 to 7 were conducted on raw water samples from four Australian reservoirs-Hope Valley, Myponga, Moorabool and Mt Zero-to assess the removal of natural organic matter (NOM) with alum. The aim was to characterize the NOM in these water sources that is highly recalcitrant to removal by alum coagulation. The selection of these water sources covered a range in raw water quality varying in inorganic and organic composition and character. NOM in both raw and treated waters was characterized by several techniques including specific UV absorbance (SUVA), high performance size exclusion chromatog. (HPSEC) and pyrolysis-gas chromatog. mass spectrometry (Py-GC-MS). The results can provide better understanding of the removal limitations of each treatment step and the knowledge will allow design engineers to select a suitable combined treatment process for optimum NOM removal. Despite the fact that the organic character of the four source waters were different, results showed that after optimized alum coagulation all four waters had a similar character. The mol. weight distribution anal. (HPSEC) indicated alum coagulation preferentially removed the higher mol. weight UV absorbing compounds while those remaining in the treated waters had the properties of lower apparent mol. weights (about 500-700 Daltons) and less UV absorbance. Py-GC-MS analyses of NOM in these waters before and after treatment indicated that polysaccharides and their derivatives are recalcitrant to removal with alum coagulation. Generally, the findings indicate that the character of the NOM is an important factor in determining its treatability.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Novakova, Veronika; Laskova, Miroslava; Vavrickova, Hana; Zimcik, Petr researched the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ).Related Products of 56413-95-7.They published the article 《Phenol-Substituted Tetrapyrazinoporphyrazines: pH-Dependent Fluorescence in Basic Media》 about this compound( cas:56413-95-7 ) in Chemistry – A European Journal. Keywords: zinc phenol substituted tetrapyrazinoporphyrazine preparation pH dependent fluorescence; phenol deprotonation switching off red fluorescence tetrapyrazinoporphyrazine solution microemulsion; azaphthalocyanines; fluorescence; intramolecular charge transfer; pH sensors; phthalocyanines. We’ll tell you more about this compound (cas:56413-95-7).

Tetrapyrazinoporphyrazines (TPyzPzs) bearing one, two, four or eight 3,5-di(tert-butyl)-4-hydroxyphenol moieties were synthesized as Zn(II) complexes and metal-free derivatives The deprotonation of the phenol using Bu4NOH induced the formation of a strong donor for intramol. charge transfer that switched OFF the red fluorescence (λF∼660 nm) of the parent Zn TPyzPzs. The changes were fully reversible for TPyzPzs with one to four phenolic moieties, and an irreversible modification was observed for TPyzPzs substituted with eight phenols. The sensors were anchored to lipophilic particles in H2O, and a pKa ∼12.5-12.7 was determined for the phenolic hydroxyl based on fluorescence changes in different buffers. A novel concept for fluorescence OFF-ON-OFF switching in metal-free TPyzPzs bearing phenolic moieties upon addition of specific amounts of base was demonstrated.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

COA of Formula: C6Cl2N4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about The synthesis, photochemical and photophysical properties of zinc aryloxy- and alkyloxyazaphthalocyanines.

Octasubstituted zinc tetrapyrazinoporphyrazines bearing butoxy, octyloxy, 2,6-diisopropylphenoxy and 4-(hydroxymethyl)phenoxy substituents were synthesized from the corresponding 5,6-disubstituted pyrazine-2,3-dicarbonitriles using Zn(quinoline)2Cl2 in yields varying from 14 to 44%. The reaction procedure proved to be efficient for the synthesis of both alkyloxy- and aryloxy- substituted zinc tetrapyrazinoporphyrazines and did not require strictly anhydrous conditions. Optimal cyclotetramerization conditions were identified for each derivative, in terms of reaction temperature, as overheating cleaved the ether bond leaving a vacant OH group on the macrocycle. The photochem. and photophys. properties of the synthesized compounds were investigated in pyridine. Singlet oxygen quantum yields (Φ Δ) ranged from 0.49 to 0.61 and high fluorescence quantum yields (Φ F) of ∼0.30 were observed for non-aggregated compounds

Here is just a brief introduction to this compound(56413-95-7)COA of Formula: C6Cl2N4, more information about the compound(5,6-Dichloropyrazine-2,3-dicarbonitrile) is in the article, you can click the link below.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56413-95-7, is researched, SMILESS is N#CC1=NC(Cl)=C(Cl)N=C1C#N, Molecular C6Cl2N4Journal, Article, Research Support, Non-U.S. Gov’t, Chemistry – A European Journal called Metal-Cation Recognition in Water by a Tetrapyrazinoporphyrazine-Based Tweezer Receptor, Author is Lochman, Lukas; Svec, Jan; Roh, Jaroslav; Kirakci, Kaplan; Lang, Kamil; Zimcik, Petr; Novakova, Veronika, the main research direction is metal cation recognition water tetrapyrazinoporphyrazine tweezer receptor; cations; crown compounds; fluorescent probes; phthalocyanines; sensors.Recommanded Product: 56413-95-7.

A series of zinc azaphthalocyanines with two azacrowns in a rigid tweezer arrangement were prepared and the fluorescence sensing properties were studied. The size-driven recognition of alkali and alk. earth metal cations was significantly enhanced by the close cooperation of the two azacrown units, in which both donor nitrogen atoms need to be involved in analyte binding to switch the sensor on. The mono- or biphasic character of the binding isotherms, together with the binding stoichiometry and magnitude of association constants (KA), indicated specific complexation of particular analytes. Water solvation was shown to play an important role and resulted in a strong quenching of sensor fluorescence in the ON state. The lead compound was embedded into silica nanoparticles and advantageous sensing properties towards K+ were demonstrated in water (λF = 671 nm, apparent KA = 82 M-1, increase of 17×), even in the presence of (supra)physiol. concentrations of Na+ and Ca2+.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Gonzalez-Tejera, M. J.; Garcia, M. V.; Sanchez de la Blanca, E.; Redondo, M. I.; Raso, M. A.; Carrillo, I. published an article about the compound: 3-Methyl-1H-pyrrole( cas:616-43-3,SMILESS:CC1=CNC=C1 ).HPLC of Formula: 616-43-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:616-43-3) through the article.

Electrochem. copolymerization of 3-methylpyrrole and N-methylpyrrole perchlorate doped was carried out at 2 overpotentials and at different electrodeposition times in MeCN medium. A mixture of instantaneous and progressive nucleation mechanisms was established from the c.d.-time transients. Doping/dedoping reversibility is deduced from the electrochem. study of copolymer films by cyclic voltammetry. FTIR spectrum anal. shows that electropolymerization time has a great influence on the random monomers proportion in the copolymer obtained. Although the copolymer conductivity is in the range of that measured for poly(3-methylpyrrole) and poly(N-methylpyrrole) obtained in similar conditions, it remains conductive for a much longer time than the homopolymers.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate