Chiral oxygen ligands

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Activation of the amide group by acylation. V. Inclusion of amino acid residues into linear and cyclic peptides》. Authors are Antonov, V. K.; Agadzhanyan, Ts. E.; Telesnina, T. R.; Shemyakin, M. M..The article about the compound:cis-4-Aminocyclohexane carboxylic acidcas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O).SDS of cas: 3685-23-2. Through the article, more information about this compound (cas:3685-23-2) is conveyed.

cf. CA 63, 16255f. Dipeptides and lactams acylated at the amide-N by amino acid residues were shown to isomerize to give corresponding linear or cyclic peptides through intermediate azocyclols, which can also undergo dehydration to form acylamidines. The transannular interaction of amide groups in 9-10-membered cyclopeptides can also result in similar acylamidines; such a process takes place during mass spectrometry of cyclopeptides. N-Phthaloylglycylglycine Et ester and azidoacetyl chloride refluxed in MePh 10 hrs. gave after filtration and evaporation 46% N-azidoacetyl-N’-phthaloylglycylglycine Et ester, m. 115-16°. Similarly were prepared 36% N-azidoacetyl-N’-phthaloylglycyl-L-leucine Et ester, m. 118-19°. The former treated with 28% HBr in AcOH overnight in the cold, diluted with Et2O, and the resulting precipitate (I) treated with Et3N in tetrahydrofuran gave 70% N-phthaloylglycylglycylglycine Et ester, m. 228-9°. Similarly was prepared N-phthaloylglycylglycyl-L-leucine Et ester, m. 155-6°. I and H2O in 5 min. gave 73% 2-phthaloylaminomethyl-3-carbethoxymethyl-Δ1-imidazolin-4-one, m. 153-4°. Similarly was obtained 63% 2-phthaloylaminomethyl-3-(1-carbethoxy-3-methylbutyl)-Δ1-imidazolin-4-one, m. 117-18°. Carbobenzoxy-β-alanyl chloride and butyrolactam in Et2O were treated at 5° with Et3N to yield in 1 day at 20° 58% N-carbobenzoxy-β-alanylbutyrolactam (II), m. 94-5°. Similar reaction with valerolactam gave N-carbobenzoxy-β-alanylvalerolactam, m. 60-1°. Similarly was prepared 50% N-carbobenzoxy-β-alanylcaprolactam, m. 60-1°. II hydrogenated over Pd in Et2O gave 38% cyclo(β-alanyl-γ-aminobutyryl) (III), m. 173°, also formed from II by treatment with 27% HBr in AcOH 45 min.; HBr salt m. 119-20°. Similarly was obtained cyclo(β-alanyl-δ-aminovaleryl) (IV), m. 187°, and 61% cyclo(β-alanyl-ε-aminocaproyl) (V), m. 259°. III heated in xylene 1 hr. under azeotropic conditions of H2O removal gave 68% 1,2-trimethylene-6-oxo-1,4,5,6-tetrahydropyrimidine (IIIa), b12 152-4°. IV similarly gave 45% 1,2-tetramethylene-6-oxo-1,4,5,6-tetrahydropyrimidine (IVa), b12 160° (no reaction took place in ο-Cl2C6H4 in 4 hrs. with V). III heated with H2O 5 min. gave 80% N-[1-aza-1-cyclopenten-2-yl]-3-aminopropionic acid (VI), decomposed 186-7°. H2NCH2CH2CO2H in MeOH was treated with O-methylbutyrolactam and gave after heating 10 min. 97% VI. Similarly O-methylvalerolactam gave 95% N-[1-aza-1-cyclohexen-2-yl]-3-aminopropionic acid, m. 186°, which heated with removal of H2O in Cl2C6H4 gave 91% IVa. Similarly O-methylcaprolactam gave 93% N-[1-aza-1-cyclohepten-2-yl]-3-aminopropionic acid, m. 200-1°, which heated in Cl2C6H4 gave 12% cyclo(β-alanyl-ε-aminocapropyl) and 80% 1,2-pentamethylene-6-oxo-1,4,5,6-tetrahydropyrimidine, b10 185-90°, m. 35°. Heating VI in xylene with removal of H2O gave IIIa. The latter kept with H2O 2 days gave VI, while H2O-Ag2O gave 32% VI and 54% cyclo(β-alanyl-γ-aminobutyryl). The above analogs of VI reacted similarly.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zimcik, Petr; Miletin, Miroslav; Ponec, Jan; Kostka, Miroslav; Fiedler, Zdenek researched the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ).Application In Synthesis of 5,6-Dichloropyrazine-2,3-dicarbonitrile.They published the article 《Synthesis and studies on photodynamic activity of new water-soluble azaphthalocyanines》 about this compound( cas:56413-95-7 ) in Journal of Photochemistry and Photobiology, A: Chemistry. Keywords: photodynamic activity water soluble azaphthalocyanine derivative; photosensitized photooxidation phenylisobenzofurane azaphthalocyanine derivative singlet oxygen generation. We’ll tell you more about this compound (cas:56413-95-7).

Aza analogs of phthalocyanines (AzaPc’s) bearing four long chains with carboxy groups at the end and four “”bulky”” diethylamino groups on periphery were synthesized and characterized. Their sodium salts are very soluble in water. The first studies on photodynamic activity of this tetrapyrazinoporphyrazines (a type of AzaPc) are presented. The dye-sensitized photooxidation of 1,3-diphenylisobenzofurane via 1O2 was studied in pyridine. Their photodynamic activity in vitro was not detected due to the aggregation behavior of these compounds in water.

Here is a brief introduction to this compound(56413-95-7)Application In Synthesis of 5,6-Dichloropyrazine-2,3-dicarbonitrile, if you want to know about other compounds related to this compound(56413-95-7), you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Synthetic Route of C7H13NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Effects of some conformationally restricted GABA analogs on GABA membrane binding and nerve ending transport. Author is Hitzemann, Robert J.; Loh, Horace H..

By using a series of aminocyclopentane- and aminocyclohexanecarboxylic acids, as well as some naturally occurring amino acids, it was possible to determine some aspects of the spatial topog. of the GABA [56-12-2] membrane binding and transport sites in the rat brain. The Na-independent GABA binding site had a different spatial topog. than the Na-dependent binding site in that (±)-trans-3-aminocyclopentanecarboxylic acid (I) [19297-28-0] was 7-fold more potent than (±)-cis-3-aminocyclopentanecarboxylic acid (II) [49805-32-5] in inhibiting Na-independent binding, but only 1.6 times more potent in inhibiting Na-dependent binding. The nerve ending GABA transport site was similar to the Na-dependent GABA binding site in that it accommodated both I and II. However, the transport site differed from the binding site in that II was a potent inhibitor of transport but a weak inhibitor of binding. In addition to the differences in spatial characteristics, differences in the subcellular distribution of Na-independent and Na-dependent binding sites were observed The former were found primarily in the nerve ending-mitochondrial fraction, whereas the latter were primarily found in the microsomal fraction.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Functional dyes derived from 2,3-dichloro-5,6-dicyanopyrazine, the main research direction is cyanopyrazine dye synthesis nucleophilic substitution; amine nucleophilic substitution dichlorodicyanopyrazine.Category: chiral-oxygen-ligands.

Chlorine nucleophilic substitution of 2,3-dichloro-5,6-dicyanopyrazine (I) with amines yielded 8 mono- or disubstituted derivatives that were tested for their second harmonic generation (SHG) and biol. activity. Triethylamine reaction with I gave a new enamine product that was characterized by NMR and IR spectroscopy. Effectiveness in controlling some plant diseases was observed

Here is a brief introduction to this compound(56413-95-7)Category: chiral-oxygen-ligands, if you want to know about other compounds related to this compound(56413-95-7), you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 616-43-3, is researched, Molecular C5H7N, about Scientific investigation of the paint and adhesive materials used in the Western Han dynasty polychromy terracotta army, Qingzhou, China, the main research direction is polychromy terracotta paint adhesive arcaheol China.Formula: C5H7N.

A royal tomb of early period of the Western Han dynasty (206 B.C-8 A.D) was excavated by archaeologists in Qingzhou County, Shandong Province in 2006. Over 2000 polychromy terracotta soldiers, horses, chariots, servants etc. were unearthed from the tomb. All the terracotta figures are one quarter or one sixth as large as the livings, most of them were painted with well designed patterns. In order to gain complete information about the materials and techniques used for the polychromy on the terracotta army, five samples from the painted areas were taken. In addition, one sample from the area to adhere one leg to the polychromy horse body was also obtained. The anal. techniques applied include XRF, FTIR, Py-GC/MS and GC/MS. Chinese purple, cinnabar, lead red and ochre were used as pigments, while animal glue was identified as binding medium and adhesive in the polychromy terracotta army in the Han Dynasty. The results definitely will provide new evidence about the materials and technologies used in Han Dynasty. Especially, the binding medium identified is different in comparison with Qin Shihuang’s terracotta army (259-210 BC).

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Application of 616-43-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about The synthesis of new 3-substituted pyrroles. Author is Stefan, Klaus Peter; Schuhmann, Wolfgang; Parlar, Harun; Korte, Friedhelm.

The synthesis of 3-alkyl-, 3-(ω-bromoalkyl)-, 3-iodo-, 3-formyl-, 3-acetyl-1-(triisopropylsilyl)pyrrole, 2-[1-(triisopropylsilyl)-3-pyrrolyl]-2-propanol, 1-(triisopropylsilyl)-3-pyrrolecarboxylic acid, and 7-[1-(triisopropylsilyl)-3-pyrrolyl]heptanoic acid as well as the desilylation of these products to the corresponding 3-substituted pyrroles is described. Intermediates in these syntheses are 1-(triisopropylsilyl)pyrrole, 3-bromo-, and 3-litho-1-(triisopropylsilyl)pyrrole.

There is still a lot of research devoted to this compound(SMILES：CC1=CNC=C1)Application of 616-43-3, and with the development of science, more effects of this compound(616-43-3) can be discovered.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

HPLC of Formula: 56413-95-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Reaction of 2,3-dichloro-5,6-dicyanopyrazine with amines. Author is Hou, Dongfeng; Matsuoka, Masaru.

Reaction of 2,3-dichloro-5,6-dicyanopyrazine (I) with amines gave mono-substituted or bis-substituted products (II; R1 = NH2, NHMe, NEt2, NMe2, pyrrolidino, morpholino; R2 = Cl, NH2, NHMe, NEt2, NHBu). Reaction if I with thioacetamide or 2,3-bis(N-methylamino)-5,6-dicyanopyrazine gave 1,4,6,9-tetraaza-2,3,7,8-tetracyanothianthrene or 2,3,7,8-tetracyano-1,4,6,9-tetraaza-5,10-dimethyl-5,10-dihydrophenazine, resp. Nonlinear optical properties for II as well as biol. activity of 2-[2-(diethylamino)vinyl]-3-chloro-5,6-dicyanopyrazine were evaluated.

There is still a lot of research devoted to this compound(SMILES：N#CC1=NC(Cl)=C(Cl)N=C1C#N)HPLC of Formula: 56413-95-7, and with the development of science, more effects of this compound(56413-95-7) can be discovered.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of α,α’-unsubstituted pyrroles》. Authors are Plieninger, H.; Buhler, W..The article about the compound:3-Methyl-1H-pyrrolecas:616-43-3,SMILESS:CC1=CNC=C1).Reference of 3-Methyl-1H-pyrrole. Through the article, more information about this compound (cas:616-43-3) is conveyed.

α,α’-Unsubstituted pyrroles were made as intermediates for the synthesis of porphyrins and bile pigments. 3-Methylpyrrole (I) and 3,4-dimethylpyrrole were obtained in 40% yield (based on the starting acetal) from MeCOCH2CH(OMe)2 (II) and MeCOCHMeCH(OMe)2, resp. II cyanohydrin was condensed with dihydropyrene (III) to give MeC(CN)(OCH.CH2.CH2.CH2.CH2.O)CH2CH(OMe)2 which was reduced to the corresponding amine with LiAlH4. Acidification liberated the pyrrole but because of further transformation in the presence of acid, it could not be isolated. Acetylation of the amine, followed by treatment with MeC6H4SO3H in absolute Me2CO, split off III, liberated the aldehyde group and gave I acetyl derivative in one step. I was obtained by careful alk. hydrolysis.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Structural factors influencing the intramolecular charge transfer and photoinduced electron transfer in tetrapyrazinoporphyrazines, published in 2014, which mentions a compound: 56413-95-7, Name is 5,6-Dichloropyrazine-2,3-dicarbonitrile, Molecular C6Cl2N4, Application of 56413-95-7.

Unsym. tetrapyrazinoporphyrazines (TPyzPzs) from the group of azaphthalocyanines with one peripherally attached amino substituent (donor) were synthesized, and their photophys. properties (fluorescence quantum yield and singlet oxygen quantum yield) were determined The synthesized TPyzPzs were expected to undergo intramol. charge transfer (ICT) as the main pathway for deactivating their excited states. Several structural factors play a critical role in ICT efficiency. The substituent in the ortho position to the donor center significantly influences the ICT, with tert-butylsulfanyl and butoxy substituents inducing the strongest ICTs, whereas chloro, Me, Ph, and hydrogen substituents in this position reduce the efficiency. The strength of the donor pos. influences the ICT efficiency and correlates well with the oxidation potential of the amines used as the substituents on the TPyzPz as follows: n-butylamine < N,N-diethylamine < aniline < phenothiazine. The ICT (with conjugated donors and acceptors) in the TPyzPz also proved to be much stronger than a photoinduced electron transfer in which the donor and the acceptor are connected through an aliphatic linker. If you want to learn more about this compound(5,6-Dichloropyrazine-2,3-dicarbonitrile)Application of 56413-95-7, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56413-95-7).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Computed Properties of C5H7N. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Organic geochemical studies of soils from Rothamsted Experimental Station: III. Nitrogen-containing organic matter in soil from Geescroft Wilderness.

Three distinct soil horizons from a mature oak dominated woodland were studied in order to determine the changes in the mol. composition of nitrogen-containing organic matter down a soil profile. The total amount of nitrogen relative to soil organic carbon increased down the profile with most of the recognizable nitrogen-containing compounds in the leaf litter and humic horizon being either amino acid or amino sugar derived. In contrast, a significant proportion of the organic nitrogen moieties in the mineral horizon appeared to contain macromol.-bound nitrogen which is believed to represent the socalled “”unknown”” soil organic nitrogen and is not obviously related to known biomols. The increase in total amino acids in the humic and mineral horizons indicated contributions from sources other than the leaf litter. The increase in organic nitrogen-containing moieties, most probably amino acids derived, accounted for the less depleted δ13C values observed in the mineral soil horizon.

If you want to learn more about this compound(3-Methyl-1H-pyrrole)Computed Properties of C5H7N, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(616-43-3).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate