Tag: M.W=100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Syntheses and characterization of push-pull tetrapyrazino[2,3-b]indoloporphyrazines》. Authors are Jaung, Jae-Yun; Matsuoka, Masaru; Fukunishi, Koushi.The article about the compound:5,6-Dichloropyrazine-2,3-dicarbonitrilecas:56413-95-7,SMILESS:N#CC1=NC(Cl)=C(Cl)N=C1C#N).Application In Synthesis of 5,6-Dichloropyrazine-2,3-dicarbonitrile. Through the article, more information about this compound (cas:56413-95-7) is conveyed.

The synthesis of tetrakis(indolopyrazino)porphyrazines by ring-closure reactions of 2,3-dichloro-5,6-dicyanopyrazine with enamines is described. Alkylated tetrakis(indolopyrazino)porphyrazines have push-pull intramol. charge-transfer chromophoric systems and show good solubility in most organic solvents. Large spectral changes caused by mol. aggregation of these dyes affected by solvent polarity and temperature were studied.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Tomura, Masaaki; Tanaka, Shoji; Yamashita, Yoshiro published the article 《Synthesis, structure and properties of the novel conducting dithiolato-metal complexes having dicyanopyrazine moieties》. Keywords: crystal structure TTF palladium cyanopyrazinethiolate 2345; TTF salt nickel palladium cyanomercaptopyrazine complex; pyrazine cyanomercapto nickel palladium complex TTF; elec conductivity TTF nickel palladium cyanomercaptopyrazine; thiolate cyanopyrazinedi nickel palladium complex; tetrathiafulvalene nickel palladium cyanopyrazinethiolate.They researched the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ).Related Products of 56413-95-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56413-95-7) here.

Novel dithiolato-metal complexes from 2,3-dicyano-5,6-dimercaptopyrazine (H2dcdmp) ligands were synthesized, and their TTF salts, (TTF)5[M(dcdmp)2]2 (M = Ni or Pd), were obtained by the diffusion method in MeCN. The elec. conductivities of these complexes at room temperature are 10-2-10-3 S cm-1. The x-ray structural anal. of (TTF)5[Pd(dcdmp)2]2 indicates that 2 Pd(dcdmp)2 mols. and 1 TTF mol. form 2:1 mixed stacks along the c axis, and other TTF mols. stack along the b axis. A number of intermol. S···N and S···S heteroatom contacts within the sum of van der Waals radii are observed in the crystal.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Kaye, B.; Brearley, C. J.; Cussans, N. J.; Herron, M.; Humphrey, M. J.; Mollatt, A. R. published an article about the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O ).Synthetic Route of C7H13NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3685-23-2) through the article.

Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo in the mouse, rat, rabbit, dog and man. Oral doses of [14C]candoxatril were cleared rapidly, mostly by ester hydrolysis to candoxatrilat, in the mouse, dog and man. A complementary i.v. study in man with [14C]candoxatrilat showed that the active drug was virtually completely renally cleared. Neither candoxatril nor candoxatrilat underwent chiral inversion in man. The systemic availability of candoxatrilat from the oral prodrug was estimated to be 88, 53, 42, 17 and 32% in the mouse, rat, rabbit, dog and man resp. Plasma clearance of candoxatril was too rapid to enable pharmacokinetic parameter calculation in mice and rabbits; for man, the apparent oral clearance was 57.9 mL/min/kg and the elimination half-life was 0.46 h. For i.v. candoxatrilat, total plasma clearance values were 32, 15, 5.5, 5.8 and 1.9 mL/min/kg for the mouse, rat, rabbit, dog and man, resp. Renal clearance values were 8.7, 7.2, 2.9 and 1.7 mL/min/kg for the mouse, rat, dog and man, resp., and these approximated the resp. glomerular filtration rates. Allometric scaling with respect to body weight across the species allowed reasonable prediction of the above 2 clearance parameters in man.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56413-95-7, is researched, Molecular C6Cl2N4, about Heavy metal effects on physicochemical properties of non-aggregated azaphthalocyanine derivatives, the main research direction is metal azaphthalocyanine derivative complex preparation fluorescence singlet oxygen yield.HPLC of Formula: 56413-95-7.

Two series of peripherally substituted azaphthalocyanines (AzaPcs) containing different transition metals (Al(III), Zn(II), Ga(III), In(III) and Fe(II)) were synthesized and studied for their photophys. properties. As confirmed by UV-visible and 1H NMR analyses, the non-aggregation behavior was effectively induced by the applied bulky peripheral substituents which had no effect on the photophys. properties. Tuning the Q-band position was clearly achievable by using different central heavy metals which have considerable effects on the fluorescence quantum yield and singlet oxygen generation efficiency. This comparative study showed an interesting linear relation between the former and at. number of the central metal. The indium containing complexes exhibited the best result due to the heavy metal effect and therefore could be promoted as a potential photosensitizer in photodynamic therapy (PDT) application.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and studies on photodynamic activity of new water-soluble azaphthalocyanines, published in 2003-02-20, which mentions a compound: 56413-95-7, mainly applied to photodynamic activity water soluble azaphthalocyanine derivative; photosensitized photooxidation phenylisobenzofurane azaphthalocyanine derivative singlet oxygen generation, Synthetic Route of C6Cl2N4.

Aza analogs of phthalocyanines (AzaPc’s) bearing four long chains with carboxy groups at the end and four “”bulky”” diethylamino groups on periphery were synthesized and characterized. Their sodium salts are very soluble in water. The first studies on photodynamic activity of this tetrapyrazinoporphyrazines (a type of AzaPc) are presented. The dye-sensitized photooxidation of 1,3-diphenylisobenzofurane via 1O2 was studied in pyridine. Their photodynamic activity in vitro was not detected due to the aggregation behavior of these compounds in water.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Electric Literature of C7H13NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis of analogs of N-(2-chloroethyl)-N’-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents. Author is Johnston, Thomas P.; McCaleb, George S.; Clayton, Sarah D.; Frye, Jerry L.; Krauth, Charles A.; Montgomery, John A..

Of several nitrosourea derivatives [X(CH2)2N(NO)CONHR (X = Cl, F; R = substituted cyclohexyl, 2-methyl-1,3-dithian-5-yl or its S, S, S’, S’-tetraoxide)] prepared and tested against murine leukemia L210 almost all were active, giving cure rates ≥50% at ≤LD10 doses. In 4 of the 5 fluoroethyl analogs activity was clearly inferior to the corresponding chloroethyl compounds Most of the more active analogs contained a 4-substituted cyclohexyl group. Activity in relation to structure, partition coefficient, and cis-trans isomerism is discussed.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Linear and cyclic peptides derived from p-aminobenzoic acid》. Authors are Langenbeck, Wolfgang; Weisbrod, Dieter.The article about the compound:cis-4-Aminocyclohexane carboxylic acidcas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O).Safety of cis-4-Aminocyclohexane carboxylic acid. Through the article, more information about this compound (cas:3685-23-2) is conveyed.

cf. CA 62, 13226b. The linear peptides N-carbobenzoxyglycyl-p-aminobenzoylglycyl-p-aminobenzoic acid (I), N-carbobenzoxy-ε-aminocaproyl-p-aminobenzoyl-ε-aminocaproic acid ethyl ester (II), and ε-aminocaproyl-p-aminobenzoyl-ε-aminocaproic acid (III) were obtained, using activated esters (method a) or the carbodiimide procedure (method b). The preparation of the cyclic peptides cyclo(ε-aminocapropyl-p-aminobenzoyl-ε-aminocaproyl-p-aminobenzoyl) (IV) and cyclo(11-aminoundecanoyl-p-aminobenzoyl) (V) was performed by cyclization of the corresponding linear peptides in diethyl phosphite with tetraethyl pyrophosphite as condensing agent. The formation of IV resulted probably from dimerization of the starting material. Because of the very small solubility of IV in all common solvents, it was impossible to determine the mol. weight p-Aminobenzoyl-ε-aminocaproic acid-HBr was prepared by hydrolysis of the N-carbobenzoxy compound To 4.1 g. N-carbobenzoxyglycyl-p-aminobenzoylglycine p-nitrophenyl ester in a mixture of 30 ml. tetrahydrofuran and 20 ml. Me2NCHO, a solution of 1.2 g. p-aminobenzoic acid and 0.35 g. NaOH in 10 ml. H2O was added. The mixture was refluxed 4 hrs. to yield 7.4% I, m. 297° (decomposition). For preparation of I using the mixed anhydride method, 3.3 g. N-carbobenzoxyglycyl-p-aminobenzoic acid, in 50 ml. tetrahydrofuran and 1.4 ml. Me3N, was treated with 1.31 ml. chlorocarbonic acid iso-Bu ester at -10°. To the reaction mixture, 2.75 g. glycyl-p-aminobenzoic acid-HBr in 20 ml. N NaOH was added and the mixture stirred 3 hrs. at 20° and 1 hr. at 40° to give 40% I. (Method a): To 3.8 g. carbobenzoxy-ε-aminocaproyl-p-aminobenzoic acid (VI) in 0.81 ml. pyridine and 50 ml. tetrahydrofuran, 1.35 ml. chlorocarbonic acid iso-Bu ester in 10 ml. tetrahydrofuran was added dropwise at -10° during 10 min., and stirring continued for 50 min. in the cold. ε-Aminocaproic acid ethyl ester-HCl (2 g.) in 10 ml. tetrahydrofuran and 0.81 ml. pyridine were added and the mixture was stirred 4 hrs. at 20° to give 28.8% II, m. 134°. (Method b) VI (3.8 g.) was dissolved in 50 ml. tetrahydrofuran, 2 g. ε-aminocaproic acid ethyl ester-HCl in 0.81 ml. pyridine and 2.1 g. dicyclohexylcarbodiimide in 5 ml. tetrahydrofuran added, and the mixture kept 24 hrs. at 20° to give 66.7% II. II (5.3 g.) was treated for 30 min. at 20° with 10 ml. HBr-HOAc to give 80.5% ε-aminocapropyl-p-aminobenzoyl-ε-aminocaproic acid ethyl ester-HBr (VII), m. 177-9°. VII (2.4 g.) was refluxed for 2 hrs. with 75 ml. Ba(OH)2 solution to give 7.2% III, m. 233° (decomposition). For cyclization, 1.324 g. ε-aminocaproyl-p-aminobenzoic acid-HBr (VIII) was dissolved in 1 l. diethyl phosphite, then 0.4 ml. pyridine and 4.85 ml. tetraethyl pyrophosphite added. The reaction mixture was stirred for 4 hrs. at 140° under N. Diethyl phosphite was distilled in vacuo, and the residue heated for 1 hr. with 100 ml. H2O and 1 l. MeOH. A white precipitate of linear oligopeptides with high mol. weight was filtered off, and 900 ml. H2O added to the filtrate, whereby further linear oligomers were precipitated, and removed by filtration. The filtrate was passed through an ion exchanger (Wofatit KPS 200, anionic, Wofatit L 150, cationic) and concentrated to 50 ml. in vacuo to give 22.6% IV, m. ∼380° (decomposition). Cyclization of VIII in the presence of tetraethyl pyrophosphite and 1.4 g. imidazole gave 23.2% IV. 11-Aminoundecanoyl-p-aminobenzoic acid-HBr (IX) [prepared in 94% yield from N-carbobenzoxy-11-aminoundecanoyl-p-aminobenzoic acid by hydrolysis with HBr-AcOH, m. 236-8° (decomposition)] (1.604 g.) in l. diethyl phosphite in the cold was treated with 0.4 ml. pyridine and 4.85 ml. tetraethyl pyrophosphite to give 23.6% V, m. 218-20°. Cyclization of IX with equivalent amounts of tetraethyl pyrophosphite and imidazole gave 21.7% IV. N-Carbobenzoxy-p-aminobenzoyl-ε-aminocaproic acid (3.8 g.) was hydrolyzed for 30 min. at 20° with 15 ml. HBr-AcOH to give 57.4% p-aminobenzoyl-ε-aminocaproic acid-HBr, m. 160°. N-Carbobenzoxy-11-aminoundecanoyl-p-aminobenzoic acid was hydrolyzed with HBr-AcOH to give 64.6% raw 11-aminoundecanoyl-p-aminobenzoic acid, m. 204-7°. p-Aminobenzoic acid was dissolved in AcOH and hydrogenated with PtO2 at 20° and atm. pressure. After 1/3 of the theoretical amount of H was absorbed, addnl. PtO2 was added. This procedure was repeated several times. When 80% of the theoretical amount of H was absorbed, the hydrogenation was stopped, and the reaction mixture worked up to give 20.9% cis-hexahydro-p-aminobenzoic acid.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ) is researched.Synthetic Route of C6Cl2N4.Hill, Jonathan P.; Subbaiyan, Navaneetha K.; D’Souza, Francis; Xie, Yongshu; Sahu, Satyajit; Sanchez-Ballester, Noelia M.; Richards, Gary J.; Mori, Toshiyuki; Ariga, Katsuhiko published the article 《Antioxidant-substituted tetrapyrazinoporphyrazine as a fluorescent sensor for basic anions》 about this compound( cas:56413-95-7 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: antioxidant tetrapyrazinoporphyrazine fluorescent sensor anion. Let’s learn more about this compound (cas:56413-95-7).

Tetrapyrazinoporphyrazine substituted at its periphery with eight antioxidant 3,5-di-t-butyl-4-hydroxyphenyl groups behaves as a turn-on fluorescent sensor for fluoride anions. Conversely, the precursor antioxidant-substituted 1,2-phthalonitrile was found to act in turn-off mode suggesting that the origin of the phenomenon lies at the phenolate-substituted 1,4-pyrazinyl moiety.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Reference of cis-4-Aminocyclohexane carboxylic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis of derivatives of stereoisomeric aminocyclohexanecarboxylic acids containing an acyl residue of p-[bis(2-chloroethyl)amino]phenylacetic acid. Author is Karpavicius, K.; Patockiene, L.; Knunyants, I. L..

Cyclohexylamines I (R = cis- and trans-4-CO2H and -CH2CO2H, H, cis-3-CO2H) reacted with 4-(ClCH2CH2)2NC6H4CH2COCl to give amides II in 55-72% yield. I (R = trans-4-CO2Et) reacted with 4-(ClCH2CH2)2NC6H4CH2CO2H in presence of dicyclohexylcarbodiimide or ClCO2Bu to give resp. II.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.Computed Properties of C7H13NO2.

The preparation and biol. evaluation of a series of indolopiperidine CCR2B receptor antagonists possessing a conformationally restricted C-5 linker chain in combination with a restricted piperidine ring are described. Compared to the parent compound, the analog I shows a dramatic improvement in selectivity against a range of 5-HT and dopaminergic receptors.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate