Tag: M.W=100-200

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-4-Aminocyclohexane carboxylic acid(SMILESS: N[C@H]1CC[C@H](CC1)C(O)=O,cas:3685-23-2) is researched.Recommanded Product: 4553-62-2. The article 《Hydrogenation of 4-aminobenzoic acid on catalysts of the platinum group》 in relation to this compound, is published in Zhurnal Organicheskoi Khimii. Let’s take a look at the latest research on this compound (cas:3685-23-2).

The rate of 4-H2NC6H4-CO2H hydrogenation to cis-4-aminocyclohexanecarboxylic acid and isomerization of the latter to the trans acid at 90-170° and 80 atm increased in the order of catalysts Pd ∼ Pt < Ru ≪ Rh and was higher with metal on C than with metal black; these reaction rates decreased in the order of solvents H2O > dioxane > EtOH > Me2SO > cyclohexylamine, and with Ru/C and Rh/C, decreased in the order of mineral acids H2SO4 > H3PO4 > HCl. At 90° the product stereochem. was determined by the reduction mechanism, and not by the rate of the secondary isomerization; the cis-trans ratio decreased in the order Ru > Rh > Pt > Pd.

From this literature《Hydrogenation of 4-aminobenzoic acid on catalysts of the platinum group》,we know some information about this compound(3685-23-2)COA of Formula: C7H13NO2, but this is not all information, there are many literatures related to this compound(3685-23-2).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Heterocyclic Chemistry called Synthesis of pyrido[1′,2′:1,2]imidazo[4,5-b]pyrazines from 2,3-dichloro-5,6-dicyanopyrazine with 2-aminopyridines, Author is Suzuki, Toshinobu; Nagae, Yasushi; Mitsuhashi, Keiryo, which mentions a compound: 56413-95-7, SMILESS is N#CC1=NC(Cl)=C(Cl)N=C1C#N, Molecular C6Cl2N4, Synthetic Route of C6Cl2N4.

Novel synthesis of the title compounds I (R = H, 6-, 7-, 8-, 9-Me, 8-Cl, 8-Br, 6-PhCH2O) by the facile cyclization between 2,3-dichloro-5,6-dicyanopyrazine and various 2-aminopyridines II under relatively mild conditions is described. The reactivity depended on the basicity of 2-aminopyridines.

From this literature《Synthesis of pyrido[1′,2′:1,2]imidazo[4,5-b]pyrazines from 2,3-dichloro-5,6-dicyanopyrazine with 2-aminopyridines》,we know some information about this compound(56413-95-7)Synthetic Route of C6Cl2N4, but this is not all information, there are many literatures related to this compound(56413-95-7).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Formula: C7H13NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Highly selective preparation of trans-4-aminocyclohexanecarboxylic acid from cis-isomer over Raney nickel catalyst. Author is Gobolos, Sandor; Banka, Zoltan; Toth, Zoltan; Szammer, Janos; Margitfalvi, Jozsef L..

4-Amino-benzoic acid was hydrogenated to 4-aminocyclohexanecarboxylic acid over alumina supported 5 weight% Ru and Rh catalysts. Complete ring saturation was achieved in 2 weight % NaOH-H2O at 80-100 °C, 10 MPa H2, and 5 h however, the ratio of trans/cis stereoisomers of the product was only between 1/3-1/1. The raw reaction mixture was further processed in the presence of a com. Raney nickel catalyst at 130°C, 100 bar H2 for 5 h. In this alkali-mediated isomerization the trans/cis isomer ratio was 7/3. The cis isomer was isolated by fractional crystallization, and then reacted on Raney nickel catalysts in 2%NaOH-H2O at 120-140°C, 1 MPa H2 for 5 h to obtain the trans isomer with a yield of ca. 70%. The two-step synthesis resulted in trans-4-aminocyclohexanecarboxylic acid with a yield above 90%. Catalytic tests were performed in a high-throughput reactor system equipped with 16 mini autoclaves.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Syntheses of 1,4,5,8-tetraazanaphthalene derivatives from diaminomaleonitrile, published in 1978-09-30, which mentions a compound: 56413-95-7, Name is 5,6-Dichloropyrazine-2,3-dicarbonitrile, Molecular C6Cl2N4, Computed Properties of C6Cl2N4.

Cyclization of diaminomaleonitrile (I) with (COCl)2 in dioxane gave 70% II. Chlorination of II by POCl3 gave 50% III. Amination off III by NH3 in DMF gave 90% IV. Cyclization of IV with (COCl)2 and chlorination by POCl3 gave 50% V. Cyclization of I with III gave 90% 2,3,6,7-tetracyano-1,4-dihydro-1,4,5,8-tetraazanaphthalene (VI). Oxidation of VI by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone gave VII.

From this literature《Syntheses of 1,4,5,8-tetraazanaphthalene derivatives from diaminomaleonitrile》,we know some information about this compound(56413-95-7)Computed Properties of C6Cl2N4, but this is not all information, there are many literatures related to this compound(56413-95-7).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Synthesis and spectral properties of tetrapyrazinoporphyrazinato metal complexes derived from a sterically hindered phenol.Related Products of 56413-95-7.

The synthesis of metal-containing tetrapyrazinoporphyrazines (azaphthalocyanines) bearing eight bulky substituents at the peripheral positions is described. The key precursor was prepared using a nucleophilic aromatic substitution reaction between a sterically hindered phenol and 5,6-dichloropyrazine-2,3-dicarbonitrile. Thus, azaphthalocyanine (AzaPc) derived from 2,6-isopropyl-4-nitrophenol possesses substituents that are forced by steric constraints to adopt a non-planar conformation which drastically enhances the solubility of the macrocycles and inhibits efficient cofacial interaction of the macrocycles even in the solid state as evaluated by UV-visible and 1H NMR spectroscopic techniques. The intense absorption in the red visible region and photostability of these highly soluble and non-aggregated complexes enhance the dynamic activity and make these complexes potentially suitable for PDT.

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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Dicyanopyrazine-derived push-pull chromophores for highly efficient photoredox catalysis, the main research direction is dicyanopyrazine photoredox catalyst optical gap absorption density functional theory.COA of Formula: C6Cl2N4.

Here, we report dicyanopyrazine (DPZ)-derived push-pull chromophores, easily prepared and tunable organic compounds, as new kinds of photoredox catalysts. In particular, the DPZ derivative H, containing 2-methoxythienyl as electron-donating moiety, exhibits a broad absorption of visible light with an absorption edge up to 500 nm and excellent redox properties, and has been demonstrated as a desirably active and efficient photoredox catalyst in four challenging kinds of photoredox reactions. The amount of catalyst in most reactions is less than 0.1 mol% and even 0.01 mol%, representing the lowest catalyst loading in the current photoredox organocatalysis.

From this literature《Dicyanopyrazine-derived push-pull chromophores for highly efficient photoredox catalysis》,we know some information about this compound(56413-95-7)COA of Formula: C6Cl2N4, but this is not all information, there are many literatures related to this compound(56413-95-7).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56413-95-7, is researched, Molecular C6Cl2N4, about A novel nickel(II) complex adopting a cis-configuration: solvothermal synthesis and crystal structure of [NiL2(H2O)4] (L = 1,4-dihydropyrazine-2,3-dione-5,6-dicarboxylate), the main research direction is nickel pyrazinedionedicarboxylate complex preparation structure; crystal structure nickel pyrazinedionedicarboxylate complex; pyrazinedicarbodinitrile reaction cadmium nickel perchlorate hydrate.Product Details of 56413-95-7.

Under solvothermal reaction conditions, the reaction of 5,6-dichloropyrazine-2,3-dicarbonitrile and [Ni(ClO4)2]·6H2O produces a novel cis-Ni(II) complex [NiL2(H2O)4] (1) (L = 1,4-dihydropyrazine-2,3-dione-5,6-dicarboxylate), whereas only hydrated 1,4-dihydropyrazine-2,3-dione-5,6-dicarboxylic acid (2) was obtained as a single phase when [Cd(ClO4)2]·6H2O was used instead of [Ni(ClO4)2]·6H2O. The crystal structure of 1 was determined

From this literature《A novel nickel(II) complex adopting a cis-configuration: solvothermal synthesis and crystal structure of [NiL2(H2O)4] (L = 1,4-dihydropyrazine-2,3-dione-5,6-dicarboxylate)》,we know some information about this compound(56413-95-7)Product Details of 56413-95-7, but this is not all information, there are many literatures related to this compound(56413-95-7).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis and biological study of bis(2-chloroethyl) sulfides containing carboxylic groups. 3. Cyclohexylamides of 3(or 4)-chloro-4(or 3)-[(2-chloroethyl)thio]butanoic acids.Computed Properties of C7H13NO2.

Cyclohexylamides Cl(CH2)2SCH(CH2Cl)CH2CONHC6H10R and Cl(CH2)2SCH2CHClCH2CONHC6H10R-4 (C6H10 = cyclohexane moiety, R = H, cis- or trans-CO2H, or -CH2CO2H, cis-β-substituted-DL-Ac-β-Ala-OH) were prepared by addition reaction of butenamides with Cl(CH2)2SCl. The biol. assay shows that the products are less toxic than analogous acids or phenylamides, whereas their antitumor effect remains high.

From this literature《Synthesis and biological study of bis(2-chloroethyl) sulfides containing carboxylic groups. 3. Cyclohexylamides of 3(or 4)-chloro-4(or 3)-[(2-chloroethyl)thio]butanoic acids》,we know some information about this compound(3685-23-2)Computed Properties of C7H13NO2, but this is not all information, there are many literatures related to this compound(3685-23-2).

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56413-95-7, is researched, Molecular C6Cl2N4, about New fused nitrogen-rich heterocycles from 5,6-dichloropyrazine-2,3-dicarbonitrile, the main research direction is pyrazinopyrazine; pyridazinopyrazine; quinoxalinopyrazine; pyrazinopyrazinopyridazine; quinoxalinopyrazinopyridazine; cyclization hydrazine pyrazinedicarbonitrile.Recommanded Product: 5,6-Dichloropyrazine-2,3-dicarbonitrile.

The reaction of the title compound with amines gave 34-82% pyrazines I (R = morpholino, piperidino, 1-pyrrolidinyl, Et2N, Me2N; RR = R1N(CH2)nNR1, R1 = Et, Ph, PhCH2, n = 2, R1 = Et, n = 3) and II (R2 = R3 = H, Me; R2 = H, R3 = Me, Cl; R2 = Me, R3 = Cl), which, upon treatment with N2H4, gave 25-61% III-V.

When you point to this article, it is believed that you are also very interested in this compound(56413-95-7)Recommanded Product: 5,6-Dichloropyrazine-2,3-dicarbonitrile and due to space limitations, I can only present the most important information.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Stereochemical investigations of 1,4-substituted cyclohexane derivatives. 4-Hydroxy- and 4-aminocyclohexane-1-carboxylic acid and their esters; and 4-hydroxy-1-hydroxymethylcyclohexane》. Authors are Schneider, Woldemar; Huettermann, A..The article about the compound:cis-4-Aminocyclohexane carboxylic acidcas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O).Recommanded Product: cis-4-Aminocyclohexane carboxylic acid. Through the article, more information about this compound (cas:3685-23-2) is conveyed.

Malonic ester synthesis with ethyl β-chloropropionate, followed by ring closure of the product obtained gave 4-hydroxy-1-cyclohexanone (I). Hydrogenation of I (Raney-Ni, atm. pressure, room temperature) in alk. medium gave cis-4-hydroxycyclohexane-1-carboxylic acid (cis-II), m. 152°; Et ester, (cis-III) b12 130°. Hydrogenation of ethyl 4-hydroxybenzoic acid (Raney-Ni, 150 atm., 150°) gave trans-III, b13 139-140°, saponification of which gave the trans-II, m. 119.5°. Reduction of trans-III with Na-EtOH or LiAlH4, gave a cis-trans mixture of 4-hydroxy-1-hydroxymethylcyclohexane (IV), from which the trans isomer (V) was separated, m. 104°; the cis isomer (VI) was recovered by distillation from the residue. Hydrogenation of ethyl 4-aminobenzoic acid (Ru-C, 110 atm., 80°) gave a cis-trans mixture of 4-amino-1-carbethoxycyclohexane (VII), which was separated by distillation, giving cis-VII and trans-VII. The exptl. determined dipole moments (μ in Debye units) of these compounds are: cis-II 2.10 ± 0.1, trans-II 246 ± 0.002, cis-III 2.86 ± 0.03, trans-III 2.56 ± 0.04, VI 2.29 ± 0.02, V 2.60 ± 0.1, cis-VII 2.60 ± 0.01, and trans-VII 2.44 ± 0.02.

When you point to this article, it is believed that you are also very interested in this compound(3685-23-2)Recommanded Product: cis-4-Aminocyclohexane carboxylic acid and due to space limitations, I can only present the most important information.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate